Evidence map›Paper›PMID 30339876›Full record

ReviewDevelopmental and comparative immunology2019

Rabbit models of human diseases for diagnostics and therapeutics development.

Rose G Mage, Pedro J Esteves, Christoph Rader

Abstract readReview
In one paragraph

Review in Developmental and comparative immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Contributions of large and agricultural animal models to immunology.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Ocular tear fluid biomarkers collected by contact lenses.Biochemical and biophysical research communications · 2024
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Modulation of Cathepsin S (Animals : an open access journal from MDPI · 2021
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Rose G MageLaboratory of Immune System Biology, NIAID, NIH, Bldg 10 11N311, 10 Center Drive, Bethesda, MD, 20892-1892, USA. Electronic address: rmage@niaid.nih.gov.
Pedro J EstevesCIBIO, InBIO, Research Network in Biodiversity and Evolutionary Biology, Universidade do Porto, Campus de Vairão, Rua Padre Armando Quintas, 4485-661, Vairão, Portugal; Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre, s/n, 4169-007, Porto, Portugal; Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde (CESPU), Gandra, Portugal.
Christoph RaderDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, 33458, USA.
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da SaúdeScripps Research Institute · US

Funding

Novel Enediyne-Based Antibody-Drug Conjugates for CancersR01CA204484 · NCI · UNIVERSITY OF FLORIDA · PI Natarajan Muthusamy, Ben Shen · 2017 to 2026
$4.6M
A Drug Delivery Strategy for Targeted Therapy of Chronic Lymphocytic LeukemiaR01CA174844 · NCI · UNIVERSITY OF FLORIDA · PI SHEN, BEN · 2018 to 2022
$3.0M
Chemically Programmed Bispecific Antibodies for Cancer TherapyR01CA181258 · NCI · SCRIPPS FLORIDA · PI RADER, CHRISTOPH · 2014 to 2018
$2.0M
NCI NIH HHS R01 CA174844NCI NIH HHS R01 CA181258NCI NIH HHS R01 CA204484
6 · The paper itself

Abstract

This review presents some examples of studies using the European rabbit (Oryctolagus cuniculus) that have led to, and continue to, contribute to advancement of understanding of human diseases as well as therapeutics development. In addition, we tabulate FDA-approved rabbit polyclonal and rabbit monoclonal antibodies (mAbs) that are used for diagnostic applications, as well as an overview of some "humanized" or otherwise altered rabbit mAbs that are in initial phase I, II, or advanced to phase III clinical trials. Information about endogenous retriviruses learned from studies of rabbits and other members of the order Lagomorpha are summarized as this knowledge now applies to new therapeutics being developed for several human diseases including Multiple Sclerosis, Type 1 Diabetes and Cancer.

Indexed as

RabbitsAnimalsClinical Trials as TopicDiabetes Mellitus, Type 1Disease Models, AnimalHumansLagomorphaMultiple SclerosisNeoplasmsUnited StatesUnited States Food and Drug AdministrationCancerCardiovascular diseaseEndogenous retrovirusesMultiple SclerosisOcular diseasesSystemic Lupus Erythematosis

Identifiers

PMID30339876
PMCPMC6364550
OpenAlexW2897043134

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.