ArticlePloS one2018
The interval between oocyte retrieval and frozen-thawed blastocyst transfer does not affect the live birth rate and obstetrical outcomes.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Delayed versus immediate frozen embryo transfer after oocyte retrieval: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2020 · on this mapPooled it
- The HERA (Hyper-response Risk Assessment) Delphi consensus for the management of hyper-responders in in vitro fertilization.Journal of assisted reproduction and genetics · 2023Article
- When Should We Freeze Embryos? Current Data for Fresh and Frozen Embryo Replacement IVF Cycles.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Whether immediate frozen-thawed embryo transfer improves IVF outcome in non-elective freeze all policy.Annals of translational medicine · 2020Article
- To delay or not frozen embryo transfer in freeze-all cycles?Annals of translational medicine · 2020Article
- Timing of frozen-thawed embryo transfers-does it really matter?Annals of translational medicine · 2020Article
- When is the optimal timing of frozen embryo transfer after controlled ovarian stimulation?Annals of translational medicine · 2020Article
- The Future of Cryopreservation in Assisted Reproductive Technologies.Frontiers in endocrinology · 2020Review
- Timing of frozen-thawed embryo transfer after controlled ovarian stimulation in a non-elective freeze-all policy.Annals of translational medicine · 2019Article
- Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe 'Freeze all' strategy, which consists of cryopreservation of all embryos after the ovarian stimulation has undergone extensive development in the past decade. The time required for the endometrium to revert to a prestimulation state after ovarian stimulation and thus the optimal time to perform a deferred embryo transfer after the stimulation has not been determined yet.
objectiveTo investigate the impact of the time from oocyte retrieval to frozen-thawed blastocyst transfer (FBT) on live birth rate (LBR), obstetrical and neonatal outcomes, in 'Freeze-all' cycle. MATERIALS AND
methodsWe conducted a large observational cohort study in a tertiary care university hospital including four hundred and seventy-four first autologous FBT performed after ovarian stimulation in 'freeze all' cycles. Reproductive outcomes were compared between FBT performed within the first menstrual cycle after the oocyte retrieval ('cycle 1' group) or delayed FBT ('cycle ≥ 2' group). The main Outcome Measure was the Live birth rate. RESULT(S): A total of 188 FBT were included in the analysis in the 'cycle 1' group and 286 in the 'cycle ≥ 2' group. No significant differences were found between FBT performed within the first menstrual cycle after oocyte retrieval (the 'cycle 1' group) and delayed FBT (the 'cycle ≥ 2' group) in terms of the live birth rate [59/188 (31.38%) vs. 85/286 (29.72%); p = 0.696] and the miscarriage rate [20/82 (24.39%) vs. 37/125 (29.60%), respectively; p = 0.413]. The obstetrical and neonatal outcomes were also not significantly different between the two groups.
conclusionOur study did not detect statistically significant differences in the LBR for FBT performed within the first menstrual cycle after oocyte retrieval versus FBT following subsequent cycles. Embryo-endometrium interaction after a FBT does not appear to be impaired by potential adverse effects of COS whatever the number of cycle between oocyte retrieval and embryo transfer.
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