ArticlePloS one2018
Transcriptomic analysis of the salivary gland of medicinal leech Hirudo nipponia.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The great diversity: monomeric and oligomeric hirudins, hirudin-like factors and decorsins in the Asian medicinal leeches Hirudo nipponia and Hirudo tianjinensis.Parasitology research · 2026Article
- Duplication of the Antistasin-Like Structure Resulted in a New Anticoagulant Protein in the Medicinal Leech.Biomolecules · 2026Article
- Article
- Chromosome-level genome assembly and anticoagulant protein annotation of the buffalo leech Hirudinaria bpling (Hirudinea: Hirudinidae).BMC genomics · 2025Article
- Diversity of hirudin and hirudin-like factor genes in the North-African medicinal leech, Hirudo troctina.Parasitology research · 2024Article
- Dysbiosis of intestinal homeostasis contribute to Whitmania pigra edema disease.Microbial biotechnology · 2023Article
- Peptidomics Analysis Reveals the Buccal Gland of Jawless Vertebrate Lamprey as a Source of Multiple Bioactive Peptides.Marine drugs · 2023Article
- Cloning, characterization, and heterologous expression of a candidate Hirudin gene from the salivary gland transcriptome of Hirudo nipponia.Scientific reports · 2023Article
- Medicinal Leech Therapy in Urology: A PRISMA-Compliant Systematic Review.African journal of urology : the official journal of the Pan African Urological Surgeons' Association (PAUSA) · 2023Article
- Comparative Transcriptome Sequencing Analysis ofFrontiers in physiology · 2022Article
- Draft genome of the European medicinal leech Hirudo medicinalis (Annelida, Clitellata, Hirudiniformes) with emphasis on anticoagulants.Scientific reports · 2020Article
- European Medicinal Leeches-New Roles in Modern Medicine.Biomedicines · 2020Review
- Spatiotemporal Expression of Anticoagulation FactorInternational journal of molecular sciences · 2019Article
- Hirudins of the Asian medicinal leech, Hirudinaria manillensis: same same, but different.Parasitology research · 2019Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Hirudo nipponia (known as Shui Zhi in Chinese) is a well-known Chinese medicine with numerous active ingredients in its body, especially in its saliva. This native Chinese blood-sucking leech has been used for therapeutic purposes since before 100 AD. Modern Chinese physicians use it for a wide range of diseases. Genomic data and molecular information about the pharmacologically active substances produced by this medicinal leech are presently unavailable despite this organism's medicinal importance. In this study, we performed transcriptome profiling of the salivary glands of medicinal leech H. nipponia using the Illumina platform. In total, 84,657,362 clean reads were assembled into 50,535 unigenes. The obtained unigenes were compared to public databases. Furthermore, a unigene sequence similarity search and comparisons with the whole transcriptome of medical leech were performed to identify potential proteins. Finally, more than 21 genes were predicted to be involved in anticoagulatory, antithrombotic, antibacterial, anti-inflammatory and antitumor processes, which might play important roles in the treatment of various diseases. This study is the first analysis of a sialotranscriptome in H. nipponia. The transcriptome profile will shed light on its genetic background and provide a useful tool to deepen our understanding of the medical value of H. nipponia.
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