ArticlePloS one2018
The relationship between resting energy expenditure and thyroid hormones in response to short-term weight loss in severe obesity.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Beyond bariatric surgery and weight loss medicaments. A systematic review of the current practice in obesity rehabilitative inpatient programs in adults and pediatrics.Frontiers in nutrition · 2022Pooled it
- Trial
- The effect of time-restricted eating accompanied by weight loss on thyroid function in adults with type 2 diabetes.Journal of the Endocrine Society · 2026Article
- Screening performance of the FINDRISC score for identification of undiagnosed type 2 diabetes in persons with severe obesity.Diabetology & metabolic syndrome · 2026Article
- Adaptive Ketogenic-Mediterranean Protocol (AKMP) in Real Clinical Practice: 14-Week Pre-Post Cohort Study on Glucolipid Markers and Safety.Nutrients · 2025Article
- The impact of weight loss interventions on thyroid function: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2025Review
- The effects of obesity on thyroid function in a metabolically healthy high-fat, high-carbohydrate diet-induced obese rat model.Frontiers in endocrinology · 2025Article
- Association of Thyroid Hormones with Basal Metabolism and Body Composition in Women of Reproductive Age.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2025Observational
- Weight History Correlates of Resting Energy Expenditure in Women With Bulimia Nervosa.The International journal of eating disorders · 2024Article
- Elevated Plasma Levels of Growth Arrest Specific 6 (Gas6) Protein in Severe Obesity: Implications for Adipose Tissue and Inflammation.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Ultrasound measurement of vastus lateralis and vastus medialis muscle parameters to identify chronic thyrotoxic myopathy.Endocrine connections · 2023Article
- Association between High Normal TSH Levels and Obesity in Women with Anti-Thyroid Autoantibodies (ATAs).Journal of clinical medicine · 2022Article
- Thyroid Function Alteration in Obesity and the Effect of Bariatric Surgery.Journal of clinical medicine · 2022Review
- Adjusted association between type 2 immunity and low risk thyroid nodules: a retrospective cohort study.BMC endocrine disorders · 2022Article
- Central Obesity Is Associated with Variations in TSH and ACTH Levels among Euthyroid Obese Individuals.International journal of endocrinology · 2022Article
- Thyroid axis hormones and anthropometric recovery of children/adolescents with overweight/obesity: A scoping review.Frontiers in nutrition · 2022Article
- The pattern of TSH and fT4 levels across different BMI ranges in a large cohort of euthyroid patients with obesity.Frontiers in endocrinology · 2022Article
- Baseline TSH levels and short-term weight loss after different procedures of bariatric surgery.International journal of obesity (2005) · 2021Article
- Article
- Irisin levels in genetic and essential obesity: clues for a potential dual role.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRegulating thermogenesis is a major task of thyroid hormones (THs), and involves TH-responsive energetic processes at the central and peripheral level. In severe obesity, little is known on the relationship between THs and resting energy expenditure (REE) before and after weight loss.
methodsWe enrolled 100 euthyroid subjects with severe obesity who were equally distributed between genders. Each was examined before and after completion of a 4-wk inpatient multidisciplinary dieting program and subjected to measurement of thyroid function, REE, fat-free mass (FFM, kg) and percent fat mass (FM).
resultsBaseline REE was lower than predicted in 70 obese patients, and overall associated with BMI, FFM and FM but not thyroid-related parameters. By the study end, both BMI and REE decreased (5.5% and 4.1%, p<0.001 vs. baseline) and their percent changes were significantly associated (p<0.05), while no association related percent changes of REE and FFM or FM. Individually, REE decreased in 66 and increased in 34 patients irrespective of gender, BMI and body composition. Weight loss significantly impacted TSH (-6.3%), FT3 (-3.3%) and FT4 levels (3.9%; p<0.001 for all). By the study end, a significant correlation became evident between REE and FT4 (r = 0.42, p<0.001) as well as FT3 (r = 0.24, p<0.05). In stepwise multivariable regression analysis, however, neither THs nor body composition entered the regression equation for REE response to weight loss.
conclusionsIn severe obesity, short-term weight loss discloses a positive relationship between REE and THs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.