ArticlePLoS biology2018
EBP1 nuclear accumulation negatively feeds back on FERONIA-mediated RALF1 signaling.
Article in PLoS biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 78 citations in OpenAlex.
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- The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize.The Plant cell · 2024Article
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- Phase separation: a new window in RALF signaling.Frontiers in plant science · 2024Article
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- Hydrogen peroxide mediates high-intensity blue light-induced hypocotyl phototropism of cotton seedlings.Stress biology · 2023Article
- Structural and biochemical basis of Arabidopsis FERONIA receptor kinase-mediated early signaling initiation.Plant communications · 2023Article
- A salt stress-activated GSO1-SOS2-SOS1 module protects the Arabidopsis root stem cell niche by enhancing sodium ion extrusion.The EMBO journal · 2023Article
- Rapid alkalinization factor: function, regulation, and potential applications in agriculture.Stress biology · 2023Review
- TheInternational journal of molecular sciences · 2023Article
- A screening of inhibitors targeting the receptor kinase FERONIA reveals small molecules that enhance plant root immunity.Plant biotechnology journal · 2023Article
- Identification of Feronia-interacting proteins in Arabidopsis thaliana.Genes & genomics · 2022Article
- Integrated omics reveal novel functions and underlying mechanisms of the receptor kinase FERONIA in Arabidopsis thaliana.The Plant cell · 2022Article
- Genome-Wide Analysis of theInternational journal of molecular sciences · 2022Article
- Plant immunity suppression via PHR1-RALF-FERONIA shapes the root microbiome to alleviate phosphate starvation.The EMBO journal · 2022Article
- bHLH11 inhibits bHLH IVc proteins by recruiting the TOPLESS/TOPLESS-RELATED corepressors.Plant physiology · 2022Article
- Linkage and association analyses reveal that hub genes in energy-flow and lipid biosynthesis pathways form a cluster in upland cotton.Computational and structural biotechnology journal · 2022Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
FERONIA (FER), a plasma membrane receptor-like kinase, is a central regulator of cell growth that integrates environmental and endogenous signals. A peptide ligand rapid alkalinization factor 1 (RALF1) binds to FER and triggers a series of downstream events, including inhibition of Arabidopsis H+-ATPase 2 activity at the cell surface and regulation of gene expression in the nucleus. We report here that, upon RALF1 binding, FER first promotes ErbB3-binding protein 1 (EBP1) mRNA translation and then interacts with and phosphorylates the EBP1 protein, leading to EBP1 accumulation in the nucleus. There, EBP1 associates with the promoters of previously identified RALF1-regulated genes, such as CML38, and regulates gene transcription in response to RALF1 signaling. EBP1 appears to inhibit the RALF1 peptide response, thus forming a transcription-translation feedback loop (TTFL) similar to that found in circadian rhythm control. The plant RALF1-FER-EBP1 axis is reminiscent of animal epidermal growth factor receptor (EGFR) signaling, in which EGF peptide induces EGFR to interact with and phosphorylate EBP1, promoting EBP1 nuclear accumulation to control cell growth. Thus, we suggest that in response to peptide signals, plant FER and animal EGFR use the conserved key regulator EBP1 to control cell growth in the nucleus.
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