Evidence map›Paper›PMID 30339360›Full record

ArticleACS applied materials & interfaces2018

Nanoparticle-Mediated Acoustic Cavitation Enables High Intensity Focused Ultrasound Ablation Without Tissue Heating.

Adem Yildirim, Dennis Shi, Shambojit Roy, Nicholas T Blum, Rajarshi Chattaraj, Jennifer N Cha, Andrew P Goodwin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Adem YildirimDepartment of Chemical and Biological Engineering , University of Colorado Boulder , Boulder , Colorado 80303 , United States.
Dennis ShiDepartment of Chemical and Biological Engineering , University of Colorado Boulder , Boulder , Colorado 80303 , United States.
Shambojit RoyDepartment of Chemical and Biological Engineering , University of Colorado Boulder , Boulder , Colorado 80303 , United States.
Nicholas T BlumDepartment of Chemical and Biological Engineering , University of Colorado Boulder , Boulder , Colorado 80303 , United States.
Rajarshi ChattarajDepartment of Mechanical Engineering , University of Colorado Boulder , Boulder , Colorado 80309 , United States.
Jennifer N ChaDepartment of Chemical and Biological Engineering , University of Colorado Boulder , Boulder , Colorado 80303 , United States.ORCID http://orcid.org/0000-0002-2840-1653
Andrew P GoodwinDepartment of Chemical and Biological Engineering , University of Colorado Boulder , Boulder , Colorado 80303 , United States.ORCID http://orcid.org/0000-0002-7284-4005

Funding

Rapid, Multiscale Sensing Using Acoustic Detection MechanismsDP2EB020401 · NIBIB · UNIVERSITY OF COLORADO · PI GOODWIN, ANDREW P · 2014 to 2017
$2.3M
Hollow Silica-Polymer Nanocomposites for Stimulus-Responsive Ultrasound ContrastR03EB021432 · NIBIB · UNIVERSITY OF COLORADO · PI GOODWIN, ANDREW P · 2016 to 2017
$154k
NIBIB NIH HHS DP2 EB020401NIBIB NIH HHS R03 EB021432
6 · The paper itself

Abstract

While thermal ablation of various solid tumors has been demonstrated using high intensity focused ultrasound (HIFU), the therapeutic outcomes of this technique are still unsatisfactory because of common recurrence of thermally ablated cancers and treatment side effects due to the high ultrasound intensity and acoustic pressure requirements. More precise ablation of tumors can be achieved by generating cavitating bubbles in the tissue using shorter pulses with higher acoustic pressures, which induce mechanical damage rather than thermal. However, it has remained as a challenge to safely deliver the acoustic pressures required for mechanical ablation of solid tumors. Here, we report a method to achieve mechanical ablation at lower acoustic pressures by utilizing phospholipid-stabilized hydrophobic mesoporous silica nanoparticles (PL-hMSN). The PL-hMSNs act as seeds for nucleation of cavitation events and thus significantly reduce the peak negative pressures and spatial-average temporal-average HIFU intensities needed to achieve mechanical ablation. Substantial mechanical damage was observed in the red blood cell or tumor spheroid containing tissue mimicking phantoms at PL-hMSN concentrations as low as 10 μg mL

Indexed as

AcousticsAnimalsCattleCell Line, TumorContrast MediaErythrocytesHot TemperatureHumansMiceNanoparticlesNeoplasmsPhantoms, ImagingPressureSilicon DioxideUltrasonic TherapyContrast MediaSilicon Dioxidecancer therapycavitationhigh intensity focused ultrasoundmesoporous silica nanoparticlestumor ablation

Identifiers

PMID30339360
PMCPMC6702128

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.