Evidence map›Paper›PMID 30339321›Full record

ReviewPigment cell & melanoma research2019

A curated gene list for expanding the horizons of pigmentation biology.

Laura L Baxter, Dawn E Watkins-Chow, William J Pavan, Stacie K Loftus

Open access · bronzeAbstract readReview
In one paragraph

Review in Pigment cell & melanoma research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 135 citations in OpenAlex.

  1. Beyond the Classics: The Synergy of AI and Genomics Reveals an Expanded Repertoire of Pigmentation Genes.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Cell type diversification and phenotype convergence underlying white fin-ornamentation of cyprinid fishes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Zoological research · 2025
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. A patient with TPCN2-related hypopigmentation and ocular phenotype.European journal of human genetics : EJHG · 2025
    Article
  18. Review
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Laura L BaxterGenetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0001-7941-1088
Dawn E Watkins-ChowGenetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland.
William J PavanGenetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland.
Stacie K LoftusGenetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0002-1958-4689
National Institutes of Health · US

Funding

Function genomic analysis of neural crest developmentZIAHG000136 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI PAVAN, WILLIAM J · 2009 to 2023
$13.6M
Intramural NIH HHS ZIA HG000136
6 · The paper itself

Abstract

Over the past century, studies of human pigmentary disorders along with mouse and zebrafish models have shed light on the many cellular functions associated with visible pigment phenotypes. This has led to numerous genes annotated with the ontology term "pigmentation" in independent human, mouse, and zebrafish databases. Comparisons among these datasets revealed that each is individually incomplete in documenting all genes involved in integument-based pigmentation phenotypes. Additionally, each database contained inherent species-specific biases in data annotation, and the term "pigmentation" did not solely reflect integument pigmentation phenotypes. This review presents a comprehensive, cross-species list of 650 genes involved in pigmentation phenotypes that was compiled with extensive manual curation of genes annotated in OMIM, MGI, ZFIN, and GO. The resulting cross-species list of genes both intrinsic and extrinsic to integument pigment cells provides a valuable tool that can be used to expand our knowledge of complex, pigmentation-associated pathways.

Indexed as

Gene Regulatory NetworksAnimalsGenesGenetic Association StudiesGenomicsHumansMutationPigmentationPolymorphism, Geneticmelaninmelanocytepigmentationskin

Identifiers

PMID30339321
PMCPMC10413850
OpenAlexW2896906082

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.