Evidence map›Paper›PMID 30339060›Full record

ArticleJournal of feline medicine and surgery2019

Radiation therapy for intracranial tumours in cats with neurological signs.

Maximilian Körner, Malgorzata Roos, Valeria S Meier, Alena Soukup, Simona Cancedda, Magdalena M Parys, Michelle Turek, Carla Rohrer Bley

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of feline medicine and surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Maximilian Körner1 Divison of Radiation Oncology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-8925-4899
Malgorzata Roos2 Department of Biostatistics, Epidemiology, Biostatistics and Prevention Institute, Faculty of Medicine, University of Zurich, Zurich, Switzerland.
Valeria S Meier1 Divison of Radiation Oncology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Alena Soukup1 Divison of Radiation Oncology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Simona Cancedda3 Centro Oncologico Veterinario, Sasso Marconi, Bologna, Italy.
Magdalena M Parys4 Royal (Dick) School of Veterinary Studies, Hospital for Small Animals, University of Edinburgh, Roslin, UK.
Michelle Turek5 Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, USA.
Carla Rohrer Bley1 Divison of Radiation Oncology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
University of Zurich · CHUniversity of Edinburgh · GBUniversity of Wisconsin–Madison · USVeterinary Oncological Center · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study was to evaluate the outcome of cats with intracranial tumours presenting with neurological signs treated with radiation therapy.

methodsThis study comprised a retrospective multicentre case series. Medical records of a total of 22 cats with intracranial space-occupying lesions, presenting with neurological signs and/or epileptic seizures and treated with external beam radiation therapy, were reviewed. In the treated cats, patient-, tumour- and treatment-related variables were investigated, including age, sex, tumour location, tumour volume, total radiation dose, equivalent dose in 2 Gy fractions (EQD

resultsBased on advanced imaging characteristics, the 22 treated cats presented with meningioma (n = 11), pituitary tumour (n = 8), choroid plexus tumour (n = 2) or glioma (n = 1). Allocated to the neuraxis, 11 lesions were extra-axial, three were intra-axial and eight were located in the pituitary region. At diagnosis, 21 cats exhibited altered neurological status. One cat presented with epileptic seizures and another cat had both seizures and altered neurological status. The mean total physical dose of radiation was 41.63 Gy (± 4.33), range 24-45 Gy. In all but one cat (95.5%), neurological signs improved after radiation therapy. The median progression-free survival was 510 days (95% confidence interval [CI]: 51-969). The proportion free of progression at 1 year was 55.7% (95% CI: 33-78). Fourteen cats died (only in five cases was death related to the intracranial tumour) and eight cats were still alive or lost to follow-up. The median overall survival time was 515 days (95% CI: 66-964). None of the tested variables influenced outcome. CONCLUSIONS AND RELEVANCE: Radiation therapy seems to represent a viable treatment option in cats with intracranial tumours, relieving neurological signs and improving local tumour control. Radiation therapy may be considered for cats with tumours in complicated/inoperable localisations or for cases with a high peri- and postoperative risk.

Indexed as

Brain NeoplasmsCat DiseasesAnimalsCatsRetrospective StudiesBrain tumourgliomaintracranialmeningiomapituitaryradiation therapyradiotherapy

Identifiers

PMID30339060
PMCPMC10814305
OpenAlexW2896945443

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.