ArticleeLife2018
Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Bst DNA Polymerase: Structure, Properties and Engineering Strategies in LAMP.International journal of molecular sciences · 2026Review
- Structural basis of multitasking by the apicoplast DNA polymerase from Plasmodium falciparum.Nucleic acids research · 2025Article
- Article
- Structures of the human leading strand Polε-PCNA holoenzyme.Nature communications · 2024Article
- Quality of Edible Sesame Oil as Obtained by Green Solvents: In Silico versus Experimental Screening Approaches.Foods (Basel, Switzerland) · 2023Article
- Molecular Characterization of a DNA Polymerase fromInternational journal of molecular sciences · 2022Article
- Rolling circle RNA synthesis catalyzed by RNA.eLife · 2022Article
- Biological and genomic characteristics of two bacteriophages isolated from sewage, using one multidrug-resistant and one non-multidrug-resistant strain ofFrontiers in microbiology · 2022Article
- Following replicative DNA synthesis by time-resolved X-ray crystallography.Nature communications · 2021Article
- In Vitro Selection of an ATP-Binding TNA Aptamer.Molecules (Basel, Switzerland) · 2020Article
- Enzymatic Cleavage of 3'-Esterified Nucleotides Enables a Long, Continuous DNA Synthesis.Scientific reports · 2020Article
- Mycobacterial DNA polymerase I: activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO-POL enzyme.Nucleic acids research · 2020Article
- Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase.Nucleic acids research · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
High resolution crystal structures of DNA polymerase intermediates are needed to study the mechanism of DNA synthesis in cells. Here we report five crystal structures of DNA polymerase I that capture new conformations for the polymerase translocation and nucleotide pre-insertion steps in the DNA synthesis pathway. We suggest that these new structures, along with previously solved structures, highlight the dynamic nature of the finger subdomain in the enzyme active site.
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Registered trials
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