ReviewAnatomical record (Hoboken, N.J. : 2007)2019
Evolution and Development of the Atrial Septum.
Review in Anatomical record (Hoboken, N.J. : 2007), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Anatomy, Histology, Aetiology, Development and Functions of Cartilago Cordis: A Systematic Review.Cells, tissues, organs · 2025Pooled it
- Pooled it
- Phosphorescence lifetime microscopy and contrast-enhanced ultrasound imaging revealed strong left-to-right intraventricular shunt in anesthetized Xenopus laevis.The journal of physiological sciences : JPS · 2026Article
- In Vivo Models of Cardiovascular Disease:Biomedicines · 2025Review
- Morphological variations of the interatrial septum and potential implications in equine cardiology.Scientific reports · 2025Article
- Developmental and Evolutionary Heart Adaptations Through Structure-Function Relationships.Journal of cardiovascular development and disease · 2025Review
- The cardiorespiratory system of miniature frogs.Journal of anatomy · 2024Article
- Genetic Alterations of Transcription Factors and Signaling Molecules Involved in the Development of Congenital Heart Defects-A Narrative Review.Children (Basel, Switzerland) · 2023Review
- Echocardiographic evaluation of the right atrial size and function: Relevance for clinical practice.American heart journal plus : cardiology research and practice · 2023Review
- Anatomy of the heart with the highest heart rate.Journal of anatomy · 2022Article
- Anuran development: A reinvestigation of the conus arteriosus and gill formation in Bufo bufo throughout metamorphosis using micro-CT.Anatomical record (Hoboken, N.J. : 2007) · 2022Article
- Morphological Study of Fossa Ovalis in Formalin-Fixed Human Hearts and Its Clinical Importance.Medicina (Kaunas, Lithuania) · 2021Article
- Role of the Epicardium in the Development of the Atrioventricular Valves and Its Relevance to the Pathogenesis of Myxomatous Valve Disease.Journal of cardiovascular development and disease · 2021Review
- The Mesenchymal Cap of the Atrial Septum and Atrial and Atrioventricular Septation.Journal of cardiovascular development and disease · 2020Review
- An Appreciation of Anatomy in the Molecular World.Journal of cardiovascular development and disease · 2020Review
- Low incidence of atrial septal defects in nonmammalian vertebrates.Evolution & development · 2020Article
- Reptiles as a Model System to Study Heart Development.Cold Spring Harbor perspectives in biology · 2020Review
- Follow Me! A Tale of Avian Heart Development with Comparisons to Mammal Heart Development.Journal of cardiovascular development and disease · 2020Review
- Development and evolution of the metazoan heart.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Review
- Comparative analysis of avian hearts provides little evidence for variation among species with acquired endothermy.Journal of morphology · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complete division of the atrial cavity by a septum, resulting in a left and right atrium, is found in many amphibians and all amniotes (reptiles, birds, and mammals). Surprisingly, it is only in eutherian, or placental, mammals that full atrial septation necessitates addition from a second septum. The high incidence of incomplete closure of the atrial septum in human, so-called probe patency, suggests this manner of closure is inefficient. We review the evolution and development of the atrial septum to understand the peculiar means of forming the atrial septum in eutherian mammals. The most primitive atrial septum is found in lungfishes and comprises a myocardial component with a mesenchymal cap on its leading edge, reminiscent to the primary atrial septum of embryonic mammals before closure of the primary foramen. In reptiles, birds, and mammals, the primary foramen is closed by the mesenchymal tissues of the atrioventricular cushions, the dorsal mesenchymal protrusion, and the mesenchymal cap. These tissues are also found in lungfishes. The closure of the primary foramen is preceded by the development of secondary perforations in the septal myocardium. In all amniotes, with the exception of eutherian mammals, the secondary perforations do not coalesce to a secondary foramen. Instead, the secondary perforations persist and are sealed by myocardial and endocardial growth after birth or hatching. We suggest that the error-prone secondary foramen allows large volumes of oxygen-rich blood to reach the cardiac left side, needed to sustain the growth of the extraordinary large offspring that characterizes eutherian mammals. Anat Rec, 302:32-48, 2019. © 2018 The Authors. The Anatomical Record published by Wiley Periodicals, Inc. on behalf of American Association of Anatomists.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.