Evidence map›Paper›PMID 30338585›Full record

ArticleMolecular microbiology2019

Heteroresistance to the model antimicrobial peptide polymyxin B in the emerging Neisseria meningitidis lineage 11.2 urethritis clade: mutations in the pilMNOPQ operon.

Yih-Ling Tzeng, Zachary Berman, Evelyn Toh, Jose A Bazan, Abigail Norris Turner, Adam C Retchless, Xin Wang, David E Nelson, David S Stephens

Open access · bronzeAbstract read
In one paragraph

Article in Molecular microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Structural analysis of resistance-nodulation cell division transporters.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  6. Polymyxins: recent advances and challenges.Frontiers in pharmacology · 2024
    Review
  7. Article
  8. Continuing genomic evolution of theMicrobial genomics · 2023
    Review
  9. Antibiotic Susceptibility Profile for the USOpen forum infectious diseases · 2023
    Article
  10. Meningococcal Urethritis: Old and New.Journal of clinical microbiology · 2022
    Review
  11. Review
  12. Article
  13. Article
  14. Colistin Resistance Mechanisms in HumanAntibiotics (Basel, Switzerland) · 2022
    Article
  15. Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Yih-Ling TzengDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.ORCID 0000-0001-7950-8197
Zachary BermanDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Evelyn TohDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Jose A BazanDivision of Infectious Diseases, Department of Internal Medicine, Ohio State University College of Medicine, Columbus, OH, 43210, USA.
Abigail Norris TurnerDivision of Infectious Diseases, Department of Internal Medicine, Ohio State University College of Medicine, Columbus, OH, 43210, USA.
Adam C RetchlessMeningitis and Vaccine Preventable Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA.
Xin WangMeningitis and Vaccine Preventable Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA.
David E NelsonDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
David S StephensDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Emory University · USCenters for Disease Control and Prevention · USIndiana University School of MedicineOhio Department of Health · USThe Ohio State University · US

Funding

The role of the urethral microbiome in idiopathic urethritis in menR01AI116706 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI NELSON, DAVID EMMET · 2016 to 2020
$3.6M
Training in STIs and infections of global health significanceT32AI007637 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI WOOLS-KALOUSTIAN, KARA KAY · 2001 to 2020
$3.4M
Clinical and molecular epidemiology of the sexual transmission of Neisseria meningitidisR01AI127863 · NIAID · OHIO STATE UNIVERSITY · PI BAZAN, JOSE A., NORRIS TURNER, ABIGAIL · 2017 to 2020
$2.9M
Rapid antimicrobial susceptibility determination of bacterial pathogensR01AI107116 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI DICKSON, ROBERT M, TZENG, YIH-LING · 2014 to 2017
$1.4M
Emergence of ST-11 Neisseria meningitidis as a sexually transmitted pathogenR21AI128313 · NIAID · EMORY UNIVERSITY · PI TZENG, YIH-LING · 2017 to 2018
$429k
National Institute of Allergy and Infectious Diseases R01AI107116National Institute of Allergy and Infectious Diseases R01AI116706National Institute of Allergy and Infectious Diseases R01AI127863National Institute of Allergy and Infectious Diseases R21AI128313NIAID NIH HHS R01 AI107116NIAID NIH HHS R01 AI116706NIAID NIH HHS R01 AI127863NIAID NIH HHS R21 AI128313NIAID NIH HHS T32 AI007637NIH HHS R01AI107116NIH HHS R01AI116706NIH HHS R01AI127863NIH HHS R21AI128313
6 · The paper itself

Abstract

Clusters of Neisseria meningitidis (Nm) urethritis among primarily heterosexual males in multiple US cities have been attributed to a unique non-encapsulated meningococcal clade (the US Nm urethritis clade, US_NmUC) within the hypervirulent clonal complex 11. Resistance to antimicrobial peptides (AMPs) is a key feature of urogenital pathogenesis of the closely related species, Neisseria gonorrhoeae. The US_NmUC isolates were found to be highly resistant to the model AMP, polymyxin B (PmB, MICs 64-256 µg ml

Indexed as

Drug Resistance, BacterialMutationAnti-Bacterial AgentsAntimicrobial Cationic PeptidesCathelicidinsCitiesColistinFimbriae ProteinsHeterosexualityHumansMaleMicrobial Sensitivity TestsMutagenesis, Site-DirectedNeisseria meningitidisOperonPolymyxin BAnti-Bacterial AgentsAntimicrobial Cationic PeptidesCathelicidinsColistinFimbriae ProteinsPolymyxin BType IV Secretion Systems

Identifiers

PMID30338585
PMCPMC6351203
OpenAlexW2897764737

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.