ArticleJournal of clinical laboratory analysis2019
Time-resolved fluorescent immunoassay-based combined detection of procalcitonin, C-reactive protein, heparin binding protein, and serum amyloid A1 to improve the diagnostic accuracy of early infection.
Article in Journal of clinical laboratory analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- The diagnostic utility of heparin-binding protein among patients with bacterial infections: a systematic review and meta-analysis.BMC infectious diseases · 2024Pooled it
- Diagnostic Value of Heparin-Binding Protein (HBP) in Pulmonary Infection After Radical Surgery for Lung Cancer: A Retrospective Study.Health science reports · 2026Article
- The Diagnostic Value of Heparin-Binding Protein for Sepsis-Associated Acute Kidney Injury: A Retrospective Single-Center Study.International journal of general medicine · 2026Article
- Establishment and Application of a Dual Immunoassay Method Based on ICP-MS for Stable Element Labeling Antibodies.Journal of clinical laboratory analysis · 2025Article
- Screening and Application of DNA Aptamers for Heparin-Binding Protein.Molecules (Basel, Switzerland) · 2024Article
- A novel HCP (heparin-binding protein-C reactive protein-procalcitonin) inflammatory composite model can predict severe acute pancreatitis.Scientific reports · 2023Article
- Multi-omics analysis reveals underlying host responses in pediatric respiratory syncytial virus pneumonia.iScience · 2023Article
- Correlation between the positive rate of SAA in children with respiratory tract infection and ambient temperature.Environmental science and pollution research international · 2021Article
- Combined detection of procalcitonin, heparin-binding protein, and interleukin-6 is a promising assay to diagnose and predict acute pancreatitis.Journal of clinical laboratory analysis · 2021Article
- Diagnostic Value of Serum Heparin Binding Protein, Blood Lactic Acid Combined with hs-CRP in Sepsis and Its Relationship with Prognosis.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- The Value of Combined Serum Amyloid A Protein and Neutrophil-to-Lymphocyte Ratio Testing in the Diagnosis and Treatment of Influenza A in Children.International journal of general medicine · 2021Article
- Acute phase protein response to viral infection and vaccination.Archives of biochemistry and biophysics · 2019Review
- Time-resolved fluorescent immunoassay-based combined detection of procalcitonin, C-reactive protein, heparin binding protein, and serum amyloid A1 to improve the diagnostic accuracy of early infection.Journal of clinical laboratory analysis · 2019Article
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5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSerological tests are indispensable in the diagnosis of early infection. At present, only procalcitonin (PCT) and C-reactive protein (CRP) are commonly used in clinical practice. Recently, serum amyloid A1 (SAA1) and heparin binding protein (HBP) have been shown to be new biomarkers, because SAA1 is highly sensitive and specific for viral infections, and HBP is predictive for septic shock. In this study, PCT, CRP, HBP, and SAA1 were detected in different combinations to improve the diagnostic accuracy of early infection using the biotin-avidin amplifying system-based time-resolved fluorescent immunoassay (BA-TRFIA).
methodsA time-resolved fluorescent immunoassay for PCT, CRP, HBP, and SAA1 was developed and then tested in a clinical setting. All experiments were carried out using the DR6608 time-resolved fluorescent immunoassay analyzer.
resultsThe cutoff values of PCT, CRP, HBP, and SAA1 were 0.05 μg/L, 5.59 mg/L, 3.83 μg/L, and 1.56 mg/L, respectively. The area under the ROC curve (AUC) showed that PCT ˃ SAA1 ˃ CRP ˃ HBP > 0.8. A methodological comparison of the results showed that a combination of the four biomarkers had the highest accuracy for the diagnosis of infectious diseases.
conclusionThe time-resolved fluorescent immunoassay-based combined detection of PCT, CRP, HBP, and SAA1 was shown to significantly improve the diagnostic accuracy of early infection. Thus, our results indicate that combined detection based on BA-TRFIA may represent a promising strategy in the clinical diagnosis of infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.