Evidence map›Paper›PMID 30338462›Full record

ArticleJournal of cancer survivorship : research and practice2018

Patterns of medication adherence in a multi-ethnic cohort of prevalent statin users diagnosed with breast, prostate, or colorectal cancer.

Matthew P Banegas, Marc A Emerson, Alyce S Adams, Ninah S Achacoso, Neetu Chawla, Stacey Alexeeff, Laurel A Habel

Abstract read
In one paragraph

Article in Journal of cancer survivorship : research and practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matthew P BanegasCenter for Health Research, Kaiser Permanente Northwest, 3800 N. Interstate Ave, Portland, OR, 97227-1110, USA. Matthew.P.Banegas@kpchr.org.ORCID 0000-0002-6158-7162
Marc A EmersonGillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Alyce S AdamsDivision of Research, Kaiser Permanente, Oakland, CA, USA.
Ninah S AchacosoDivision of Research, Kaiser Permanente, Oakland, CA, USA.
Neetu ChawlaDivision of Research, Kaiser Permanente, Oakland, CA, USA.
Stacey AlexeeffDivision of Research, Kaiser Permanente, Oakland, CA, USA.
Laurel A HabelDivision of Research, Kaiser Permanente, Oakland, CA, USA.

Funding

CRN4: Cancer Research Resources & Collaboration in Integrated Health Care SystemsU24CA171524 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI KUSHI, LAWRENCE H · 2012 to 2016
$16.0M
Pharmaceuticals and CancerR01CA098838 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI HABEL, LAUREL A · 2004 to 2013
$3.2M
Impact of Medicare Part D on Cancer and Diabetes Disparities among Dual EnrolleesR01AG032249 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI ADAMS, ALYCE SOPHIA · 2009 to 2011
$1.5M
NCI NIH HHS R01 CA098838NCI NIH HHS U24 CA171524NIA NIH HHS R01 AG032249
6 · The paper itself

Abstract

purposeTo investigate the implications of a cancer diagnosis on medication adherence for pre-existing comorbid conditions, we explored statin adherence patterns prior to and following a new diagnosis of breast, colorectal, or prostate cancer among a multi-ethnic cohort.

methodsWe identified adults enrolled at Kaiser Permanente Northern California who were prevalent statin medication users, newly diagnosed with breast, colorectal, or prostate cancer between 2000 and 2012. Statin adherence was measured using the proportion of days covered (PDC) during the 2-year pre-cancer diagnosis and the 2-year post-cancer diagnosis. Adherence patterns were assessed using generalized estimating equations, for all cancers combined and stratified by cancer type and race/ethnicity, adjusted for demographic, clinical, and tumor characteristics.

resultsAmong 10,177 cancer patients, statin adherence decreased from pre- to post-cancer diagnosis (adjusted odds ratio (OR

conclusionsWe found substantial variation in statin medication adherence following diagnosis by cancer type and race/ethnicity among a large cohort of prevalent statin users in an integrated health care setting. IMPLICATIONS FOR CANCER SURVIVORS: Improving our understanding of comorbidity management and polypharmacy across diverse cancer patient populations is warranted to develop tailored interventions that improve medication adherence and reduce disparities in health outcomes.

Indexed as

Drug MonitoringMedication AdherenceAdultAgedAged, 80 and overBreast NeoplasmsCaliforniaCohort StudiesColorectal NeoplasmsEthnicityFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypercholesterolemiaMaleMiddle AgedHydroxymethylglutaryl-CoA Reductase InhibitorsAdherenceBreast cancerColorectal cancerComorbiditiesProstate cancerRace/ethnicity

Identifiers

PMID30338462
PMCPMC6238633

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.