ArticleEuropean radiology2019
Brain microstructural alterations in type 2 diabetes: diffusion kurtosis imaging provides added value to diffusion tensor imaging.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Abnormalities of Brain White Matter in Type 2 Diabetes Mellitus: A Meta-Analysis of Diffusion Tensor Imaging.Frontiers in aging neuroscience · 2021Pooled it
- Relationship Between Type 2 Diabetes and White Matter Hyperintensity: A Systematic Review.Frontiers in endocrinology · 2020Pooled it
- Diffusion Magnetic Resonance Imaging Models for Detecting Brain Microstructural Abnormalities in Type 2 Diabetes: A Systematic Review.Bioengineering (Basel, Switzerland) · 2026Review
- A Multimodal MRI Study of the White Matter Microstructural and Hemodynamic Underpinnings of Cognitive Decline in Type 2 Diabetes Mellitus.Brain topography · 2026Article
- Brain Microstructural Alteration and Its Implications for Postoperative Delirium in Elderly Surgical Patients: A Narrative Review.Brain and behavior · 2025Review
- White Matter Microstructural Alterations in Type 2 Diabetes: A Combined UK Biobank Study of Diffusion Tensor Imaging and Neurite Orientation Dispersion and Density Imaging.Medicina (Kaunas, Lithuania) · 2025Article
- Network efficiency of functional brain connectomes altered in type 2 diabetes patients with and without mild cognitive impairment.Diabetology & metabolic syndrome · 2024Article
- Diabetes-related clinical and microstructural white matter changes in patients with Alzheimer's disease.Brain and behavior · 2024Article
- White matter microstructure alterations in type 2 diabetes mellitus and its correlation with cerebral small vessel disease and cognitive performance.Scientific reports · 2024Article
- Diffusion and functional MRI reveal microstructural and network connectivity impairment in adult-onset neuronal intranuclear inclusion disease.Frontiers in aging neuroscience · 2024Article
- The role of neurovascular coupling dysfunction in cognitive decline of diabetes patients.Frontiers in neuroscience · 2024Review
- Analysis of white matter tract integrity using diffusion kurtosis imaging reveals the correlation of white matter microstructural abnormalities with cognitive impairment in type 2 diabetes mellitus.Frontiers in endocrinology · 2024Article
- White Matter Characteristics of Damage Along Fiber Tracts in Patients with Type 2 Diabetes Mellitus.Clinical neuroradiology · 2023Article
- Renal functional and interstitial fibrotic assessment with non-Gaussian diffusion kurtosis imaging.Insights into imaging · 2022Article
- Differences in structural connectivity between diabetic and psychological erectile dysfunction revealed by network-based statistic: A diffusion tensor imaging study.Frontiers in endocrinology · 2022Article
- Noninvasive evaluation of early diabetic nephropathy using diffusion kurtosis imaging: an experimental study.European radiology · 2021Article
- Investigating Brain Microstructural Alterations in Type 1 and Type 2 Diabetes Using Diffusion Tensor Imaging: A Systematic Review.Brain sciences · 2021Review
- Implementation of Imaging Methods in Evaluation of T2DM-Correlated Brain Alterations and Cognitive Dysfunction.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2020Review
- Alterations of Brain Structural Network Connectivity in Type 2 Diabetes Mellitus Patients With Mild Cognitive Impairment.Frontiers in aging neuroscience · 2020Article
- White Matter Atrophy in Type 2 Diabetes Mellitus Patients With Mild Cognitive Impairment.Frontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesTo investigate brain microstructural changes in white matter and gray matter of type 2 diabetes mellitus (T2DM) patients using diffusion kurtosis imaging.
methodsDiffusion kurtosis imaging (b values = 0, 1250, and 2500 s/mm
resultsIn whole-brain tract-based spatial statistics analysis, T2DM patients exhibited abnormalities in 29.6%, 30.4%, 35.4%, 10.5%, and 26.0% of white matter regions as measured by FA, MD, MK, K
conclusionsDiffusion kurtosis imaging detects more brain regions with white matter and gray matter microstructural alterations of T2DM patients than DTI metrics. It provides valuable information for studying the pathology of diabetic encephalopathy and may lead to better imaging biomarkers for monitoring disease progression. KEY POINTS: • Diffusion kurtosis imaging detects more brain regions with microstructural alterations in white matter and gray matter of T2DM patients than DTI. • Mean kurtosis changes are associated with disease severity and impaired neuropsychological function in T2DM. • Diffusion kurtosis imaging demonstrates potential to assess cognitive impairment in T2DM patients and predict disease progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.