Evidence map›Paper›PMID 30338346›Full record

ArticleVirchows Archiv : an international journal of pathology2019

Insulin-like growth factor-1 receptor expression in upper tract urothelial carcinoma.

Marie-Lisa Eich, Aline C Tregnago, Sheila F Faraj, Doreen N Palsgrove, Kazutoshi Fujita, Stephania M Bezerra, Enrico Munari, Rajni Sharma, Alcides Chaux, George J Netto

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Novel, emerging and provisional renal entities: The Genitourinary Pathology Society (GUPS) update on renal neoplasia.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021
    Guideline
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Expression of Nectin-4 and PD-L1 in Upper Tract Urothelial Carcinoma.International journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Marie-Lisa EichDepartment of Pathology, The University of Alabama at Birmingham, WP Building, Suite P230 l 619 19th Street, South, Birmingham, AL, 35249-7331, USA.
Aline C TregnagoDepartment of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Sheila F FarajDepartment of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Doreen N PalsgroveDepartment of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Kazutoshi FujitaDepartment of Urology, Osaka University, Osaka, Japan.
Stephania M BezerraDepartment of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Enrico MunariDepartment of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Rajni SharmaDepartment of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Alcides ChauxNorte University, Asunción, Paraguay.
George J NettoDepartment of Pathology, The University of Alabama at Birmingham, WP Building, Suite P230 l 619 19th Street, South, Birmingham, AL, 35249-7331, USA. gnetto@uabmc.edu.ORCID http://orcid.org/0000-0003-3915-9134
Johns Hopkins University · USUniversity of Alabama at Birmingham · USThe University of Osaka · JPUniversidad del Norte · PY

Funding

Opportunities for Pathology Trainees in Cancer ResearchT32CA193145 · NCI · JOHNS HOPKINS UNIVERSITY · PI ANDERS, ROBERT A., EBERHART, CHARLES G · 2015 to 2025
$2.6M
NCI NIH HHS T32 CA193145
6 · The paper itself

Abstract

Insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase receptor that plays a crucial role in cell proliferation, growth, differentiation, and apoptosis. IGF1R overexpression has been observed in several cancers, including invasive bladder carcinomas, as a potential prognostic factor. Given known biologic differences between upper and lower urinary tract urothelial carcinoma, we assessed the expression status and prognostic significance of IGF1R in upper tract urothelial carcinoma (UTUC). Two tissue microarrays (TMAs) were built from 99 Japanese patients with non-metastatic UTUC submitted to radical nephroureterectomy between 1997 and 2011. TMAs were constructed with triplicate tumor and paired benign urothelium. Membranous IGF1R staining was evaluated using immunohistochemistry. Two scoring methods were applied (Her2-score and H-score). The highest score was assigned to each tumor. IGF1R positivity was defined as Her2-score ≥ 1+. Association with clinicopathologic parameters and outcome was assessed using hazard ratios (HR) with 95% confidence intervals (CI) and adjusted P values. We found positive IGF1R expression in 70% of UTUC. Outcomes were as follows: tumor recurrence, 33%; tumor progression, 59%; overall mortality, 33%; and cancer-specific mortality, 30%. IGF1R was not associated with any clinicopathologic features. In addition, IGF1R expression was not associated with tumor recurrence (HR = 0.54, CI = 0.25-1.1, P = 0.11), tumor progression (HR = 1.6, CI = 0.8-3.1, P = 0.19), overall mortality (HR = 1.5, CI = 0.68-3.4, P = 0.31), or cancer-specific mortality (HR = 1.6, CI = 0.68-3.8, P = 0.27). Positive IGF1R expression was found in more than two thirds of UTUC. This finding provides a rationale to investigate IGF1R as a potential therapeutic target in UTUC. In contrast to bladder cancer, IGF1R expression in UTUC did not correlate with outcome, further pointing to biologic differences between UTUC and bladder cancer.

Indexed as

AgedAged, 80 and overBiomarkers, TumorCarcinomaDisease ProgressionFemaleHumansImmunohistochemistryJapanKidney NeoplasmsMaleMiddle AgedNeoplasm Recurrence, LocalReceptor, IGF Type 1Receptors, SomatomedinRetrospective StudiesBiomarkers, TumorIGF1R protein, humanReceptor, IGF Type 1Receptors, SomatomedinIGF1RInsulin-like growth factor-1 receptorUpper tract urothelial carcinomaUrothelial carcinoma

Identifiers

PMID30338346
PMCPMC6730551
OpenAlexW2896463043

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.