Evidence map›Paper›PMID 30338292›Full record

ArticleScience advances2018

Mitochondrial oxidation of the carbohydrate fuel is required for neural precursor/stem cell function and postnatal cerebellar development.

Hong Zheng, Wen-Mei Yu, Jinhua Shen, Sumin Kang, Dolores Hambardzumyan, James Y Li, Yuxian Shen, Anna M Kenney, Jing Chen, Cheng-Kui Qu

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Brain development and bioenergetic changes.Neurobiology of disease · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. The critical role of cardiolipin in metazoan differentiation, development, and maturation.Developmental dynamics : an official publication of the American Association of Anatomists · 2023
    Review
  13. High SPATA18 Expression and its Diagnostic and Prognostic Value in Clear Cell Renal Cell Carcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2023
    Article
  14. Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Hong ZhengDepartment of Pediatrics, Children's Healthcare of Atlanta, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-4048-6530
Wen-Mei YuDepartment of Pediatrics, Children's Healthcare of Atlanta, Emory University, Atlanta, GA 30322, USA.
Jinhua ShenDepartment of Medicine, Center for Stem Cell and Regenerative Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Sumin KangDepartment of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322, USA.
Dolores HambardzumyanDepartment of Pediatrics, Children's Healthcare of Atlanta, Emory University, Atlanta, GA 30322, USA.
James Y LiDepartment of Genetics and Genome Sciences, University of Connecticut, Farmington, CT 06030, USA.ORCID 0000-0002-9231-2698
Yuxian ShenSchool of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
Anna M KenneyDepartment of Pediatrics, Children's Healthcare of Atlanta, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0001-8323-0618
Jing ChenDepartment of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322, USA.
Cheng-Kui QuDepartment of Pediatrics, Children's Healthcare of Atlanta, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-4256-8652
Emory University · USAnhui Medical University · CNCase Western Reserve University · USUniversity of Connecticut · US

Funding

Germline mutations of PTPN11 (SHP2) in the stem cell microenvironmentR01HL130995 · NHLBI · EMORY UNIVERSITY · PI QU, CHENG-KUI · 2016 to 2024
$3.3M
Metabolic regulation of hematopoietic stem cellsR01DK092722 · NIDDK · EMORY UNIVERSITY · PI QU, CHENG-KUI · 2011 to 2019
$2.5M
NHLBI NIH HHS R01 HL130995NIDDK NIH HHS R01 DK092722
6 · The paper itself

Abstract

While deregulation of mitochondrial metabolism and cytosolic glycolysis has been well recognized in tumor cells, the role of coordinated mitochondrial oxidation and cytosolic fermentation of pyruvate, a key metabolite derived from glucose, in physiological processes is not well understood. Here, we report that knockout of

Indexed as

AnimalsAnimals, NewbornCarbohydrate MetabolismCell Cycle CheckpointsCerebellumFemaleGlycolysisMaleMice, KnockoutMitochondriaNeural Stem CellsProtein Tyrosine PhosphatasesPTEN PhosphohydrolasePyruvic AcidProtein Tyrosine PhosphatasesPTEN PhosphohydrolasePtpmt1 protein, mousePyruvic Acid

Identifiers

PMID30338292
PMCPMC6191298
OpenAlexW2897089591

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.