Evidence map›Paper›PMID 30338257›Full record

ReviewFrontiers in bioengineering and biotechnology2018

Systems and Synthetic Biology Approaches to Engineer Fungi for Fine Chemical Production.

Leonardo Martins-Santana, Luisa C Nora, Ananda Sanches-Medeiros, Gabriel L Lovate, Murilo H A Cassiano, Rafael Silva-Rocha

Abstract readReview
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Microorganisms · 2022
    Review
  6. Review
  7. Article
  8. Mining novelFrontiers in microbiology · 2022
    Article
  9. Review
  10. Molecular Characterization of XyloglucanaseInternational journal of molecular sciences · 2021
    Article
  11. Review
  12. The Model SystemLife (Basel, Switzerland) · 2020
    Review
  13. A Systems-Based Approach for Cyanide Overproduction byFrontiers in bioengineering and biotechnology · 2020
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Leonardo Martins-SantanaSystems and Synthetic Biology Laboratory, Cell and Molecular Biology Department, Ribeirão Preto Medical School, São Paulo University (FMRP-USP), Ribeirão Preto, Brazil.
Luisa C NoraSystems and Synthetic Biology Laboratory, Cell and Molecular Biology Department, Ribeirão Preto Medical School, São Paulo University (FMRP-USP), Ribeirão Preto, Brazil.
Ananda Sanches-MedeirosSystems and Synthetic Biology Laboratory, Cell and Molecular Biology Department, Ribeirão Preto Medical School, São Paulo University (FMRP-USP), Ribeirão Preto, Brazil.
Gabriel L LovateSystems and Synthetic Biology Laboratory, Cell and Molecular Biology Department, Ribeirão Preto Medical School, São Paulo University (FMRP-USP), Ribeirão Preto, Brazil.
Murilo H A CassianoSystems and Synthetic Biology Laboratory, Cell and Molecular Biology Department, Ribeirão Preto Medical School, São Paulo University (FMRP-USP), Ribeirão Preto, Brazil.
Rafael Silva-RochaSystems and Synthetic Biology Laboratory, Cell and Molecular Biology Department, Ribeirão Preto Medical School, São Paulo University (FMRP-USP), Ribeirão Preto, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the advent of systems and synthetic biology, many studies have sought to harness microbes as cell factories through genetic and metabolic engineering approaches. Yeast and filamentous fungi have been successfully harnessed to produce fine and high value-added chemical products. In this review, we present some of the most promising advances from recent years in the use of fungi for this purpose, focusing on the manipulation of fungal strains using systems and synthetic biology tools to improve metabolic flow and the flow of secondary metabolites by pathway redesign. We also review the roles of bioinformatics analysis and predictions in synthetic circuits, highlighting

Indexed as

bioinformaticsbiotechnologyfilamentous fungigenetic engineeringsynthetic biologyyeast

Identifiers

PMID30338257
PMCPMC6178918

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.