Evidence map›Paper›PMID 30338152›Full record

ArticleBiomedical optics express2018

Deep learning based detection of cone photoreceptors with multimodal adaptive optics scanning light ophthalmoscope images of achromatopsia.

David Cunefare, Christopher S Langlo, Emily J Patterson, Sarah Blau, Alfredo Dubra, Joseph Carroll, Sina Farsiu

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Adaptive Optics Imaging of Inherited Retinal Disease.Cold Spring Harbor perspectives in medicine · 2023
    Review
  5. Article
  6. Foveal Cone Structure in Patients With Blue Cone Monochromacy.Investigative ophthalmology & visual science · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Adaptive optics for high-resolution imaging.Nature reviews. Methods primers · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. SPATIALLY INFORMED CNN FOR AUTOMATED CONE DETECTION IN ADAPTIVE OPTICS RETINAL IMAGES.Proceedings. IEEE International Symposium on Biomedical Imaging · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

David CunefareDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Christopher S LangloDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Emily J PattersonDepartment of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Sarah BlauDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Alfredo DubraDepartment of Ophthalmology, Stanford University, Palo Alto, CA 94303, USA.
Joseph CarrollDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Sina FarsiuDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Duke University · USMedical College of Wisconsin · USStanford University · US

Funding

VISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI Vadim Y Arshavsky · 1985 to 2026
$19.3M
MORPHOLOGY MODULEP30EY001931 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI LINK, BRIAN A · 1985 to 2016
$9.8M
Assessing Photoreceptor Structure and Function in Normal and Diseased RetinaeR01EY017607 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI Joseph Carroll · 2008 to 2026
$8.3M
Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
Platform Technologies for Microscopic Retinal Imaging: Development & TranslationU01EY025477 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO · 2015 to 2019
$4.4M
Training in Medical ImagingT32EB001040 · NIBIB · DUKE UNIVERSITY · PI NIGHTINGALE, KATHRYN RADABAUGH · 2003 to 2018
$4.4M
Axially-resolved Spectroscopic Ophthalmic ImagingR01EY025231 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO · 2015 to 2019
$1.9M
Handheld Portable Adaptive Optics Scanning Laser Ophthalmoscope for Imaging Young ChildrenR21EY027086 · NEI · DUKE UNIVERSITY · PI FARSIU, SINA, IZATT, JOSEPH A · 2016 to 2017
$425k
NEI NIH HHS P30 EY001931NEI NIH HHS P30 EY005722NEI NIH HHS P30 EY026877NEI NIH HHS R01 EY017607NEI NIH HHS R01 EY025231NEI NIH HHS R21 EY027086NEI NIH HHS U01 EY025477NIBIB NIH HHS T32 EB001040
6 · The paper itself

Abstract

Fast and reliable quantification of cone photoreceptors is a bottleneck in the clinical utilization of adaptive optics scanning light ophthalmoscope (AOSLO) systems for the study, diagnosis, and prognosis of retinal diseases. To-date, manual grading has been the sole reliable source of AOSLO quantification, as no automatic method has been reliably utilized for cone detection in real-world low-quality images of diseased retina. We present a novel deep learning based approach that combines information from both the confocal and non-confocal split detector AOSLO modalities to detect cones in subjects with achromatopsia. Our dual-mode deep learning based approach outperforms the state-of-the-art automated techniques and is on a par with human grading.

Indexed as

(100.2960) Image analysis(100.4996) Pattern recognition, neural networks(110.1080) Active or adaptive optics(170.4470) Ophthalmology

Identifiers

PMID30338152
PMCPMC6191607
OpenAlexW2884526620

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.