ArticleBiomedical optics express2018
Noninvasive
Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 66 citations in OpenAlex.
- Article
- Red Blood Cell Distribution and Volume Changes at Capillary Junctions in the Living Human Retina.Investigative ophthalmology & visual science · 2025Article
- Pulsatile flow in a thin-walled viscoelastic tube.Journal of fluid mechanics · 2025Article
- A High-Fidelity Computational Model for Predicting Blood Cell Trafficking and 3D Capillary Hemodynamics in Retinal Microvascular Networks.Investigative ophthalmology & visual science · 2024Article
- Plexus-Specific Retinal Capillary Blood Flow Analysis Using Erythrocyte Mediated Angiography and Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2024Article
- Measurement of retinal blood flow precision in the human eye with multimodal adaptive optics imaging.Biomedical optics express · 2024Article
- Compact Linear Flow Phantom Model for Retinal Blood-Flow Evaluation.Diagnostics (Basel, Switzerland) · 2024Article
- High-speed, phase contrast retinal and blood flow imaging using an adaptive optics partially confocal multi-line ophthalmoscope.Biomedical optics express · 2024Article
- Changes to the shape, orientation and packing of red cells as a function of retinal capillary size.Biomedical optics express · 2024Article
- Validation of an automated method for studying retinal capillary blood flow.Biomedical optics express · 2024Article
- Flow Heterogeneity and Factors Contributing to the Variability in Retinal Capillary Blood Flow.Investigative ophthalmology & visual science · 2023Article
- Differential reductions in the capillary red-blood-cell flux between retina and brain under chronic global hypoperfusion.Neurophotonics · 2023Article
- Retinal blood flow speed quantification at the capillary level using temporal autocorrelation fitting OCTA [Invited].Biomedical optics express · 2023Article
- High-speed measurement of retinal arterial blood flow in the living human eye with adaptive optics ophthalmoscopy.Optics letters · 2023Article
- Evolution of adaptive optics retinal imaging [Invited].Biomedical optics express · 2023Review
- Article
- Twenty-five years of clinical applications using adaptive optics ophthalmoscopy [Invited].Biomedical optics express · 2023Review
- In Vivo Capillary Structure and Blood Cell Flux in the Normal and Diabetic Mouse Eye.Investigative ophthalmology & visual science · 2022Article
- Computational investigation of blood cell transport in retinal microaneurysms.PLoS computational biology · 2022Article
- Imaging the Retinal Vasculature.Annual review of vision science · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The flow of erythrocytes in parafoveal capillaries was imaged in the living human eye with an adaptive optics near-confocal ophthalmoscope at a frame rate of 800 Hz with a low coherence near-infrared (NIR) light source. Spatiotemporal traces of the erythrocyte movement were extracted from consecutive images. Erythrocyte velocity was measured using custom software based on the Radon transform. The impact of imaging speed on velocity measurement was estimated using images of frame rates of 200, 400, and 800 Hz. The NIR light allowed for long imaging periods without visually stimulating the retina and disturbing the natural rheological state. High speed near-confocal imaging enabled direct and accurate measurement of erythrocyte velocity, and revealed a distinctively cardiac-dependent pulsatile velocity waveform of the erythrocyte flow in retinal capillaries, disclosed the impact of the leukocytes on erythrocyte motion, and provided new metrics for precise assessment of erythrocyte movement. The approach may facilitate new investigations on the pathophysiology of retinal microcirculation with applications for ocular and systemic diseases.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.