ArticleBiomedical optics express2018
Spatially confined quantification of bilirubin concentrations by spectroscopic visible-light optical coherence tomography.
Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Comparative Analysis of Classification of Neonatal Bilirubin by Using Various Machine Learning Approaches.Cureus · 2024Article
- Tracking the dynamics of thrombus formation in a blood vessel-on-chip with visible-light optical coherence tomography.Biomedical optics express · 2023Article
- Design and characterization of color printed polyurethane films as biomedical phantom layers.Biomedical optics express · 2023Article
- Quantification of cephalocaudal progression of jaundice in preterm infants.Pediatric research · 2023Article
- Optical density based quantification of total haemoglobin concentrations with spectroscopic optical coherence tomography.Scientific reports · 2021Article
- Inter-device reproducibility of transcutaneous bilirubin meters.Pediatric research · 2021Article
- Visible light optical coherence tomography angiography (vis-OCTA) facilitates local microvascular oximetry in the human retina.Biomedical optics express · 2020Article
- Spatially compounded plane wave imaging using a laser-induced ultrasound source.Photoacoustics · 2020Article
- Dependency of the optical scattering properties of human milk on casein content and common sample preparation methods.Journal of biomedical optics · 2020Article
- Hyperspectral optical coherence tomography for in vivo visualization of melanin in the retinal pigment epithelium.Journal of biophotonics · 2019Article
- Ultrahigh-resolution optical coherence tomography/angiography with an economic and compact supercontinuum laser.Biomedical optics express · 2019Article
- Quantification of total haemoglobin concentrations in human whole blood by spectroscopic visible-light optical coherence tomography.Scientific reports · 2019Article
- How skin anatomy influences transcutaneous bilirubin determinations: an in vitro evaluation.Pediatric research · 2019Article
- Optical properties of human milk.Biomedical optics express · 2019Article
- Noninvasive transcutaneous bilirubin assessment of neonates with hyperbilirubinemia using a photon diffusion theory-based method.Biomedical optics express · 2019Article
- Light scattering methods for tissue diagnosis.Optica · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spatially confined measurements of bilirubin in tissue can be of great value for noninvasive bilirubin estimations during neonatal jaundice, as well as our understanding of the physiology behind bilirubin extravasation. This work shows the potential of spectroscopic visible-light optical coherence tomography (sOCT) for this purpose. At the bilirubin absorption peak around 460 nm, sOCT suffers from a strong signal decay with depth, which we overcome by optimizing our system sensitivity through a combination of zero-delay acquisition and focus tracking. In a phantom study, we demonstrate the quantification of bilirubin concentrations between 0 and 650 µM with only a 10% difference to the expected value, thereby covering the entire clinical pathophysiological range.
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