Evidence map›Paper›PMID 30338140›Full record

ArticleBiomedical optics express2018

Label-free fluorescence lifetime spectroscopy detects radiation-induced necrotic changes in live brain in real-time.

Brad A Hartl, Htet S W Ma, Shamira Sridharan, Katherine S Hansen, Michael S Kent, Fredric Gorin, Ruben C Fragoso, Laura Marcu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Decoding Optical Data with Machine Learning.Laser & photonics reviews · 2021
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Brad A HartlDepartment of Biomedical Engineering, University of California, Davis, CA 95616, USA.
Htet S W MaDepartment of Biomedical Engineering, University of California, Davis, CA 95616, USA.
Shamira SridharanDepartment of Biomedical Engineering, University of California, Davis, CA 95616, USA.
Katherine S HansenDepartment of Surgical and Radiological Sciences, University of California Davis School of Veterinary Medicine, Davis, CA 95616, USA.
Michael S KentDepartment of Surgical and Radiological Sciences, University of California Davis School of Veterinary Medicine, Davis, CA 95616, USA.
Fredric GorinDepartment of Neurology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
Ruben C FragosoDepartment of Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
Laura MarcuDepartment of Biomedical Engineering, University of California, Davis, CA 95616, USA.
University of California, Davis · US

Funding

Fluorescence lifetime technique for detection of radiation necrosis vs gliomR21CA178578 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MARCU, LAURA · 2014 to 2015
$360k
NCI NIH HHS R21 CA178578
6 · The paper itself

Abstract

Current clinical imaging modalities do not reliably identify brain tissue regions with necrosis following radiotherapy. This creates challenges for stereotaxic biopsies and surgical-decision making. Time-resolved fluorescence spectroscopy (TRFS) provides a means to rapidly identify necrotic tissue by its distinct autofluorescence signature resulting from tissue breakdown and altered metabolic profiles in regions with radiation damage. Studies conducted in a live animal model of radiation necrosis demonstrated that necrotic tissue is characterized by respective increases of 27% and 108% in average lifetime and redox ratio, when compared with healthy tissue. Moreover, radiation-damaged tissue not visible by MRI but confirmed by histopathology, was detected by TRFS. Current results demonstrate the ability of TRFS to identify radiation-damaged brain tissue in real-time and indicates its potential to assist with surgical guidance and MRI-guided biopsy procedures.

Indexed as

(170.3650) Lifetime-based sensing(170.4580) Optical diagnostics for medicine(170.6280) Spectroscopy, fluorescence and luminescence(300.2530) Fluorescence, laser-induced

Identifiers

PMID30338140
PMCPMC6191615
OpenAlexW2862188506

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.