ArticleObesity science & practice2018
Association of plasma nitrite levels with obesity and metabolic syndrome in the Old Order Amish.
Article in Obesity science & practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- The association between dietary intakes of nitrate and nitrite and odds of metabolic syndrome and its component in adults.Scientific reports · 2026Article
- Circulating Nitric Oxide and Metabolic Syndrome in Arab Children and Adolescents: A Case-Control Study.Children (Basel, Switzerland) · 2023Article
- The relationship between dietary patterns and overweight and obesity among adult in Jiangsu Province of China: a structural equation model.BMC public health · 2021Article
- Seasonal affective disorder and seasonal changes in weight and sleep duration are inversely associated with plasma adiponectin levels.Journal of psychiatric research · 2020Article
- Plasma soluble P-selectin correlates with triglycerides and nitrite in overweight/obese patients with schizophrenia.Pteridines · 2020Article
- Association of plasma nitrite levels with obesity and metabolic syndrome in the Old Order Amish.Obesity science & practice · 2018Article
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 6 countries.
Funding
Abstract
objectivesPlasma nitrite is a metabolite of nitric oxide and reflects endogenous nitric oxide synthase (NOS) activity. Although plasma nitrites were previously linked with obesity and metabolic syndrome (MetS), the direction of association remains inconsistent, possibly due to sample heterogeneity. In a relatively homogeneous population, we hypothesized that nitrite levels will be positively associated with overweight/obesity and MetS.
methodsFasting nitrite levels were measured in 116 Old Order Amish (78% women). We performed age-and-sex-adjusted ancovas to compare nitrite levels between three groups (a) overweight/obese(-)MetS(-), (b) overweight/obese(+)MetS(-) and (c) overweight/obese(+)MetS)(+). Multivariate linear regressions were conducted on nitrite associations with continuous metabolic variables, with successive adjustments for demographics, body mass index, C-reactive protein and neopterin.
resultsNitrite levels were higher in the obese/overweight(+)MetS(+) group than in the other two groups (
conclusionFurther investigation of the connection between obesity/MetS and plasma nitrite levels may lead to novel dietary and pharmacological approaches that ultimately may contribute to reducing the increasing burden of obesity, MetS and cardiovascular morbidity and mortality.
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Registered trials
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