Evidence map›Paper›PMID 30338047›Full record

ArticleMolecular autism2018

Links between looking and speaking in autism and first-degree relatives: insights into the expression of genetic liability to autism.

Kritika Nayar, Peter C Gordon, Gary E Martin, Abigail L Hogan, Chelsea La Valle, Walker McKinney, Michelle Lee, Elizabeth S Norton, Molly Losh

Open access · goldAbstract read
In one paragraph

Article in Molecular autism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Narrative Ability in Autism and First-Degree Relatives.Journal of autism and developmental disorders · 2025
    Article
  5. Article
  6. Review
  7. Neural Processing of Speech Sounds in ASD and First-Degree Relatives.Journal of autism and developmental disorders · 2023
    Article
  8. Article
  9. A cross-cultural study of visual attention in autism spectrum disorder.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2023
    Article
  10. Article
  11. Article
  12. Article
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  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kritika Nayar1Northwestern University, Evanston, USA.
Peter C Gordon2University of North Carolina at Chapel Hill, Chapel Hill, USA.
Gary E Martin3St. John's University, New York City, USA.
Abigail L Hogan1Northwestern University, Evanston, USA.
Chelsea La Valle1Northwestern University, Evanston, USA.
Walker McKinney1Northwestern University, Evanston, USA.
Michelle Lee1Northwestern University, Evanston, USA.
Elizabeth S Norton1Northwestern University, Evanston, USA.
Molly Losh1Northwestern University, Evanston, USA.
Northwestern University · USSt. John's University · USUniversity of North Carolina at Chapel Hill · US

Funding

UNC MRDD Research CenterP30HD003110 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BELGER, AYSENIL · 1985 to 2012
$28.7M
A Family-Genetic Study of Language in AutismR01DC010191 · NIDCD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Molly C Losh · 2010 to 2026
$7.8M
NICHD NIH HHS P30 HD003110NIDCD NIH HHS R01 DC010191
6 · The paper itself

Abstract

Background: Rapid automatized naming (RAN; naming of familiar items presented in an array) is a task that taps fundamental neurocognitive processes that are affected in a number of complex psychiatric conditions. Deficits in RAN have been repeatedly observed in autism spectrum disorder (ASD), and also among first-degree relatives, suggesting that RAN may tap features that index genetic liability to ASD. This study used eye tracking to examine neurocognitive mechanisms related to RAN performance in ASD and first-degree relatives, and investigated links to broader language and clinical-behavioral features. Methods: Fifty-one individuals with ASD, biological parents of individuals with ASD ( Results: Both the ASD and parent-ASD groups showed slower naming times, more errors, and atypical eye-movement patterns (e.g., increased fixations and refixations), relative to controls, with differences persisting after accounting for spousal resemblance. RAN ability and associated eye movement patterns were correlated with increased social-communicative impairment and increased repetitive behaviors in ASD. Longer RAN times and greater refixations in the parent-ASD group were driven by the subgroup who showed clinical-behavioral features of the broad autism phenotype (BAP). Finally, parent-child dyad correlations revealed associations between naming time and refixations in parents with the BAP and increased repetitive behaviors in their child with ASD. Conclusions: Differences in RAN performance and associated eye movement patterns detected in ASD and in parents, and links to broader social-communicative abilities, clinical features, and parent-child associations, suggest that RAN-related abilities might constitute genetically meaningful neurocognitive markers that can help bridge connections between underlying biology and ASD symptomatology.

Indexed as

AdolescentAdultAutism Spectrum DisorderChildCommunicationEye MovementsFemaleHumansMaleMiddle AgedParentsSocial BehaviorYoung AdultAutism spectrum disorderBroad autism phenotypeEndophenotypeEye movementEye-voice spanGazeLanguageRapid automatized namingRestricted and repetitive behaviorsSocial communication

Identifiers

PMID30338047
PMCPMC6180594
OpenAlexW2896927741

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.