Evidence map›Paper›PMID 30337958›Full record

ReviewBiotechnology for biofuels2018

From beech wood to itaconic acid: case study on biorefinery process integration.

Lars Regestein, Tobias Klement, Philipp Grande, Dirk Kreyenschulte, Benedikt Heyman, Tim Maßmann, Armin Eggert, Robert Sengpiel, Yumei Wang, Nick Wierckx and 8 more

Open access · goldAbstract readReview
In one paragraph

Review in Biotechnology for biofuels, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 77 citations in OpenAlex.

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  14. An OptimizedJournal of fungi (Basel, Switzerland) · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Lars Regestein1AVT-Bio-chemical Engineering, RWTH Aachen University, Forckenbeckstr. 51, 52074 Aachen, Germany.
Tobias Klement1AVT-Bio-chemical Engineering, RWTH Aachen University, Forckenbeckstr. 51, 52074 Aachen, Germany.
Philipp Grande5Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Worringerweg 2, 52064 Aachen, Germany.
Dirk Kreyenschulte1AVT-Bio-chemical Engineering, RWTH Aachen University, Forckenbeckstr. 51, 52074 Aachen, Germany.
Benedikt Heyman1AVT-Bio-chemical Engineering, RWTH Aachen University, Forckenbeckstr. 51, 52074 Aachen, Germany.
Tim Maßmann3AVT-Fluid Process Engineering, RWTH Aachen University, Forckenbeckstr. 51, 52074 Aachen, Germany.
Armin Eggert3AVT-Fluid Process Engineering, RWTH Aachen University, Forckenbeckstr. 51, 52074 Aachen, Germany.
Robert Sengpiel2AVT-Chemical Process Engineering, RWTH Aachen University, Forckenbeckstr. 51, 52074 Aachen, Germany.
Yumei Wang4AVT-Enzyme Process Technology, RWTH Aachen University, Forckenbeckstr. 51, 52074 Aachen, Germany.
Nick Wierckx7iAMB-Institute of Applied Microbiology, RWTH Aachen University, Worringerweg 1, 52064 Aachen, Germany.
Lars M Blank7iAMB-Institute of Applied Microbiology, RWTH Aachen University, Worringerweg 1, 52064 Aachen, Germany.
Antje Spiess4AVT-Enzyme Process Technology, RWTH Aachen University, Forckenbeckstr. 51, 52074 Aachen, Germany.
Walter Leitner5Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Worringerweg 2, 52064 Aachen, Germany.
Carsten Bolm11Institut für Organische Chemie, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.
Matthias Wessling2AVT-Chemical Process Engineering, RWTH Aachen University, Forckenbeckstr. 51, 52074 Aachen, Germany.
Andreas Jupke3AVT-Fluid Process Engineering, RWTH Aachen University, Forckenbeckstr. 51, 52074 Aachen, Germany.
Miriam Rosenbaum7iAMB-Institute of Applied Microbiology, RWTH Aachen University, Worringerweg 1, 52064 Aachen, Germany.
Jochen Büchs1AVT-Bio-chemical Engineering, RWTH Aachen University, Forckenbeckstr. 51, 52074 Aachen, Germany.
RWTH Aachen University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renewable raw materials in sustainable biorefinery processes pose new challenges to the manufacturing routes of platform chemicals. Beside the investigations of individual unit operations, the research on process chains, leading from plant biomass to the final products like lactic acid, succinic acid, and itaconic acid is increasing. This article presents a complete process chain from wooden biomass to the platform chemical itaconic acid. The process starts with the mechanical pretreatment of beech wood, which subsequently is subjected to chemo-catalytic biomass fractionation (OrganoCat) into three phases, which comprise cellulose pulp, aqueous hydrolyzed hemicellulose, and organic lignin solutions. Lignin is transferred to further chemical valorization. The aqueous phase containing oxalic acid as well as hemi-cellulosic sugars is treated by nanofiltration to recycle the acid catalyst back to the chemo-catalytic pretreatment and to concentrate the sugar hydrolysate. In a parallel step, the cellulose pulp is enzymatically hydrolyzed to yield glucose, which-together with the pentose-rich stream-can be used as a carbon source in the fermentation. The fermentation of the sugar fraction into itaconic acid can either be performed with the established fungi

Indexed as

Bio-based platform chemicalBio-chemical conversionBioeconomyBiorefinery processItaconic acid

Identifiers

PMID30337958
PMCPMC6180396
OpenAlexW2896597401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.