Evidence map›Paper›PMID 30337944›Full record

ArticleTissue engineering and regenerative medicine2016

Bioreactor Conditioning of Valve Scaffolds Seeded Internally with Adult Stem Cells.

Allison Kennamer, Leslie Sierad, Richard Pascal, Nicholas Rierson, Christopher Albers, Marius Harpa, Ovidiu Cotoi, Lucian Harceaga, Peter Olah, Preda Terezia and 2 more

Abstract read
In one paragraph

Article in Tissue engineering and regenerative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Allison KennamerBiocompatibility and Tissue Regeneration Laboratories, Department of Bioengineering, Clemson University, Clemson, SC, USA.
Leslie SieradBiocompatibility and Tissue Regeneration Laboratories, Department of Bioengineering, Clemson University, Clemson, SC, USA.
Richard PascalBiocompatibility and Tissue Regeneration Laboratories, Department of Bioengineering, Clemson University, Clemson, SC, USA.
Nicholas RiersonBiocompatibility and Tissue Regeneration Laboratories, Department of Bioengineering, Clemson University, Clemson, SC, USA.
Christopher AlbersBiocompatibility and Tissue Regeneration Laboratories, Department of Bioengineering, Clemson University, Clemson, SC, USA.
Marius HarpaTissue Engineering and Regenerative Medicine Laboratory, Department of Anatomy, University of Medicine and Pharmacy, Targu Mures, Romania.
Ovidiu CotoiTissue Engineering and Regenerative Medicine Laboratory, Department of Anatomy, University of Medicine and Pharmacy, Targu Mures, Romania.
Lucian HarceagaTissue Engineering and Regenerative Medicine Laboratory, Department of Anatomy, University of Medicine and Pharmacy, Targu Mures, Romania.
Peter OlahTissue Engineering and Regenerative Medicine Laboratory, Department of Anatomy, University of Medicine and Pharmacy, Targu Mures, Romania.
Preda TereziaTissue Engineering and Regenerative Medicine Laboratory, Department of Anatomy, University of Medicine and Pharmacy, Targu Mures, Romania.
Agneta SimionescuCardiovascular Tissue Engineering and Regenerative Medicine Laboratory, Department of Bioengineering, Clemson University, Clemson, SC, USA.
Dan SimionescuBiocompatibility and Tissue Regeneration Laboratories, Department of Bioengineering, Clemson University, Clemson, SC, USA.
Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș · ROClemson University · USBiocom · US

Funding

Functional tissue engineering and regeneration of the aortic rootR56HL130950 · NHLBI · CLEMSON UNIVERSITY · PI GIMBLE, JEFFREY MARTIN, SIERAD, LESLIE NEIL · 2016 to 2016
$404k
NHLBI NIH HHS R56 HL130950
6 · The paper itself

Abstract

The goal of this study was to test the hypothesis that stem cells, as a response to valve-specific extracellular matrix "niches" and mechanical stimuli, would differentiate into valvular interstitial cells (VICs). Porcine aortic root scaffolds were prepared by decellularization. After verifying that roots exhibited adequate hemodynamics

Indexed as

BioreactorHeart valvesScaffoldsStem cells

Identifiers

PMID30337944
PMCPMC6170839
OpenAlexW2526242438

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.