Evidence map›Paper›PMID 30337928›Full record

ArticleFrontiers in immunology2018

Innate Immunity Induces the Accumulation of Lung Mast Cells During Influenza Infection.

Behdad Zarnegar, Annika Westin, Syrmoula Evangelidou, Jenny Hallgren

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Circulating mast cell progenitors correlate with reduced lung function in allergic asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019
    Trial
  2. Review
  3. Article
  4. Article
  5. Elastase- and LPS-Exposed Cpa3Frontiers in immunology · 2022
    Article
  6. Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Behdad ZarnegarDepartment of Medical Biochemistry and Microbiology, BMC, Uppsala University, Uppsala, Sweden.
Annika WestinDepartment of Medical Biochemistry and Microbiology, BMC, Uppsala University, Uppsala, Sweden.
Syrmoula EvangelidouDepartment of Medical Biochemistry and Microbiology, BMC, Uppsala University, Uppsala, Sweden.
Jenny HallgrenDepartment of Medical Biochemistry and Microbiology, BMC, Uppsala University, Uppsala, Sweden.
Uppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mast cells release disease-causing mediators and accumulate in the lung of asthmatics. The most common cause of exacerbations of asthma is respiratory virus infections such as influenza. Recently, we demonstrated that influenza infection in mice triggers the recruitment of mast cell progenitors to the lung. This process starts early after infection and leads to the accumulation of mast cells. Previous studies showed that an adaptive immune response was required to trigger the recruitment of mast cell progenitors to the lung in a mouse model of allergic lung inflammation. Therefore, we set out to determine whether an adaptive immune response against the virus is needed to cause the influenza-induced recruitment of mast cell progenitors to the lung. We found that influenza-induced recruitment of mast cell progenitors to the lung was intact in

Indexed as

Immunity, InnateAdaptive ImmunityAnimalsCell MovementCytokinesDisease Models, AnimalDNA-Binding ProteinsHost-Pathogen InteractionsInterleukin-1 Receptor-Like 1 ProteinInterleukin-33LungMast CellsMiceMice, KnockoutOrthomyxoviridae InfectionsPoly I-CCytokinesDNA-Binding ProteinsIl1rl1 protein, mouseInterleukin-1 Receptor-Like 1 ProteinInterleukin-33Poly I-CRag2 protein, mouseinfluenzamast cellsmouse modelST2TLR3

Identifiers

PMID30337928
PMCPMC6180200
OpenAlexW2895204042

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.