Evidence map›Paper›PMID 30337922›Full record

ReviewFrontiers in immunology2018

Catestatin as a Target for Treatment of Inflammatory Diseases.

Elke M Muntjewerff, Gina Dunkel, Mara J T Nicolasen, Sushil K Mahata, Geert van den Bogaart

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Serum Catestatin Level as a Novel Biomarker of Oral Lichen Planus.Medical sciences (Basel, Switzerland) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The role of chromogranin A cleavage products in onset of type 1 and 2 diabetes.Frontiers in clinical diabetes and healthcare · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Catestatin in Cardiovascular Diseases.International journal of molecular sciences · 2025
    Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Elke M MuntjewerffDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
Gina DunkelDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
Mara J T NicolasenDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
Sushil K MahataVA San Diego Healthcare System, San Diego, CA, United States.
Geert van den BogaartDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
Radboud University Medical Center · NLRadboud Institute for Molecular Life Sciences · NLUniversity of California, San Diego · USUniversity of Groningen · NL

Funding

Role of Chromogranin A in Metabolic SyndromeI01BX000323 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI MAHATA, SUSHIL K · 2011 to 2013
–
Catestatin improves glucose homeostasis and insulin sensitivity in diet-induced obese miceI01BX003934 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI MAHATA, SUSHIL K · 2018 to 2021
–
BLRD VA I01 BX000323BLRD VA I01 BX003934
6 · The paper itself

Abstract

It is increasingly clear that inflammatory diseases and cancers are influenced by cleavage products of the pro-hormone chromogranin A (CgA), such as the 21-amino acids long catestatin (CST). The goal of this review is to provide an overview of the anti-inflammatory effects of CST and its mechanism of action. We discuss evidence proving that CST and its precursor CgA are crucial for maintaining metabolic and immune homeostasis. CST could reduce inflammation in various mouse models for diabetes, colitis and atherosclerosis. In these mouse models, CST treatment resulted in less infiltration of immune cells in affected tissues, although

Indexed as

AtherosclerosisColitisDiabetes Mellitus, ExperimentalMacrophagesAnimalsCell DifferentiationChromogranin ADrug Delivery SystemsHumansInflammationMicePeptide FragmentsChromogranin Achromogranin A (344-364)Peptide Fragmentsanti-inflammatorycatestatinchromogranin Aimmune modulationinflammatory diseasemacrophages

Identifiers

PMID30337922
PMCPMC6180191
OpenAlexW2895524111

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.