ArticleJournal of ginseng research2018
Bioactivity-guided isolation of ginsenosides from Korean Red Ginseng with cytotoxic activity against human lung adenocarcinoma cells.
Article in Journal of ginseng research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Comprehensive PRISMA Based Systematic Review: Exploring the Phytochemistry, Pharmacological Profile and Clinical aspects ofCurrent topics in medicinal chemistry · 2025Pooled it
- Ginseng-derived compounds as potential anticancer agents targeting cancer stem cells.Journal of ginseng research · 2024Review
- Bioassay-guided isolation of three new alkaloids fromFrontiers in microbiology · 2024Article
- (20R)-panaxadiol improves obesity by promoting white fat beigeing.Frontiers in pharmacology · 2023Article
- Analysis of metabolites and metabolism-mediated biological activity assessment of ginsenosides on microfluidic co-culture system.Frontiers in pharmacology · 2023Article
- Red ginseng polysaccharide exhibits anticancer activity through GPX4 downregulation-induced ferroptosis.Pharmaceutical biology · 2022Article
- Ginsenoside Rb1 fromMolecules (Basel, Switzerland) · 2022Article
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- Ginsenoside Rg1 Suppresses Non-Small-Cell Lung Cancer via MicroRNA-126-PI3K-AKT-mTOR Pathway.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Transcriptome expression profile of compound-K-enriched red ginseng extract (DDK-401) in Korean volunteers and its apoptotic properties.Frontiers in pharmacology · 2022Article
- The promising therapeutic potentials of ginsenosides mediated through p38 MAPK signaling inhibition.Heliyon · 2021Review
- Pharmacological properties of ginsenosides in inflammation-derived cancers.Molecular and cellular biochemistry · 2021Review
- Pharmacological potential of ginseng and its major component ginsenosides.Journal of ginseng research · 2021Review
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- Ergostane-Type Steroids from Korean Wild MushroomJournal of microbiology and biotechnology · 2020Article
- Hepatoprotective Potency of Chrysophanol 8-International journal of molecular sciences · 2020Article
- Diketoacetonylphenalenone, Derived from Hawaiian Volcanic Soil-Associated FungusMolecules (Basel, Switzerland) · 2020Article
- Identification of Anti-Inflammatory Compounds from Hawaiian Noni (Molecules (Basel, Switzerland) · 2020Article
- The Effects of Triterpenoid Saponins from the Seeds ofPlants (Basel, Switzerland) · 2020Article
- Discovery of Dihydrophaseic Acid Glucosides from the Florets ofPlants (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLung cancer is the leading cause of cancer-related death worldwide. In this study, we used a bioactivity-guided isolation technique to identify constituents of Korean Red Ginseng (KRG) with antiproliferative activity against human lung adenocarcinoma cells.
methodsBioactivity-guided fractionation and preparative/semipreparative HPLC purification were used with LC/MS analysis to separate the bioactive constituents. Cell viability and apoptosis in human lung cancer cell lines (A549, H1264, H1299, and Calu-6) after treatment with KRG extract fractions and constituents thereof were assessed using the water-soluble tetrazolium salt (WST-1) assay and terminal deoxyribonucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining, respectively. Caspase activation was assessed by detecting its surrogate marker, cleaved poly adenosine diphosphate (ADP-ribose) polymerase, using an immunoblot assay. The expression and subcellular localization of apoptosis-inducing factor were assessed using immunoblotting and immunofluorescence, respectively. RESULTS AND
conclusionBioactivity-guided fractionation of the KRG extract revealed that its ethyl acetate-soluble fraction exerts significant cytotoxic activity against all human lung cancer cell lines tested by inducing apoptosis. Chemical investigation of the ethyl acetatesoluble fraction led to the isolation of six ginsenosides, including ginsenoside Rb1 (
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