Evidence map›Paper›PMID 30337607›Full record

ArticleScientific reports2018

Prevalence of Strongyloides stercoralis infection and hyperinfection syndrome among renal allograft recipients in Central Europe.

Wolfgang Winnicki, Michael Eder, Peter Mazal, Florian J Mayer, Gürkan Sengölge, Ludwig Wagner

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Guideline
  2. Prevalence of Strongyloides stercoralis in haemodialysis patients in Vienna.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026
    Article
  3. Article
  4. Article
  5. Seroprevalence ofTropical medicine and infectious disease · 2023
    Article
  6. Tropical medicine and infectious disease · 2022
    Review
  7. Article
  8. BMJ open · 2022
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Autochthonous Human and CaninePathogens (Basel, Switzerland) · 2020
    Review
  16. Article
  17. Article
  18. Disease markers · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Wolfgang WinnickiDepartment of Internal Medicine III; Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria. wolfgang.winnicki@meduniwien.ac.at.ORCID http://orcid.org/0000-0002-0511-6120
Michael EderDepartment of Internal Medicine III; Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-6341-1275
Peter MazalDepartment of Clinical Pathology, Medical University of Vienna, Vienna, Austria.
Florian J MayerDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Gürkan SengölgeDepartment of Internal Medicine III; Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria.
Ludwig WagnerDepartment of Internal Medicine III; Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria.
Medical University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Strongyloides stercoralis is not hyperendemic in European countries but has been increasing in prevalence due to migration and travel. The infection is characterized by a mostly asymptomatic course or nonspecific symptoms in healthy subjects. However, immunosuppression or chemotherapy have been described as leading triggers for Strongyloides stercoralis hyperinfection syndrome and may have a fatal course. A post hoc analysis was performed among renal transplant patients during a 5-year period. Plasma samples of two hundred kidney allograft recipients were retrospectively analyzed for Strongyloides stercoralis seropositivity by established ELISA testing. Positive Strongyloides stercoralis serology was found in 3% of allograft recipients. One patient developed a life-threatening hyperinfection syndrome. His Strongyloides IgG signal had been elevated for years before the outbreak of the disease. Stronglyoides infections in transplant recipients are an important issue that physicians also in Central Europe should be aware of, given the risk of hyperinfection syndrome and the challenges in clinical diagnosis. Our study suggests that recipient and donor screening should be recommended in kidney transplantation programs in Central Europe as Strongyloides infection rates increase and its prevalence may be underestimated. Further research is needed to understand why some Strongyloides stercoralis seropositive individuals develop hyperinfection syndrome and others do not.

Indexed as

Strongyloides stercoralisAdultAgedAnimalsCase-Control StudiesEuropeHumansImmunosuppression TherapyKidney TransplantationMiddle AgedPrevalenceRetrospective StudiesSeroepidemiologic StudiesStrongyloidiasisSystemic Inflammatory Response SyndromeTransplantation, Homologous

Identifiers

PMID30337607
PMCPMC6194009
OpenAlexW2897280564

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.