ArticleScientific reports2018
Genomic analysis of Acinetobacter baumannii prophages reveals remarkable diversity and suggests profound impact on bacterial virulence and fitness.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- A One Health perspective on mobile genetic elements and associated antibiotic resistance genes in non-humanApplied and environmental microbiology · 2026Review
- Nested mobile genetic elements mediating antimicrobial resistance genes mobility within and betweeniScience · 2026Article
- Genus-wide Homologous Recombination of Tail Fibers Maintains Tailocin Diversity in Pectobacterium.Genome biology and evolution · 2026Article
- Prophage: agent provocateur?Archives of microbiology · 2026Review
- Carbapenem-ResistantMicroorganisms · 2025Review
- Impact of Natural Transformation on the Acquisition of Novel Genes in Bacteria.Molecular biology and evolution · 2025Article
- Pangenomics to understand prophage dynamics in theMicrobial genomics · 2025Article
- Exploring Viral Interactions inLife (Basel, Switzerland) · 2025Article
- Bacteriophages: A Challenge for Antimicrobial Therapy.Microorganisms · 2025Review
- Identifying phage Lysins through genomic analysis of prophages fromFrontiers in microbiology · 2025Article
- Genomic analysis of prophages in 44 clinical strains ofFrontiers in cellular and infection microbiology · 2025Article
- Geographic variation in abundance and diversity ofFrontiers in microbiology · 2025Article
- Genomic Insights into Bacterial Antimicrobial Resistance Transmission and Mitigation Strategies.Current pharmaceutical biotechnology · 2025Review
- Deciphering the Intracellular Action of the Antimicrobial Peptide A11 via an In-Depth Analysis of Its Effect on the Global Proteome ofACS infectious diseases · 2024Article
- Pan-Genome Plasticity and Virulence Factors: A Natural Treasure Trove forAntibiotics (Basel, Switzerland) · 2024Review
- Appelmans protocol - A directed in vitro evolution enables induction and recombination of prophages with expanded host range.Virus research · 2024Article
- Prediction and characterization of prophages of Stenotrophomonas maltophilia reveals a remarkable phylogenetic diversity of prophages.Scientific reports · 2023Article
- The Role of Mobile Genetic Elements in Virulence Factor Carriage from Symptomatic and Asymptomatic Cases of Escherichia coli Bacteriuria.Microbiology spectrum · 2023Article
- Characterization and Diversity ofInternational journal of molecular sciences · 2023Article
- Systematic analysis of prophage elements in actinobacterial genomes reveals a remarkable phylogenetic diversity.Scientific reports · 2023Article
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3 authors.
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Abstract
The recent nomination by the World Health Organization of Acinetobacter baumannii as the number one priority pathogen for the development of new antibiotics is a direct consequence of its fast evolution of pathogenicity, and in particular of multidrug resistance. While the development of new antibiotics is critical, understanding the mechanisms behind the crescent bacterial antibiotic resistance is equally relevant. Often, resistance and other bacterial virulence elements are contained on highly mobile pieces of DNA that can easily spread to other bacteria. Prophages are one of the mediators of this form of gene transfer, and have been frequently found in bacterial genomes, often offering advantageous features to the host. Here we assess the contribution of prophages for the evolution of A. baumannii pathogenicity. We found prophages to be notably diverse and widely disseminated in A. baumannii genomes. Also remarkably, A. baumannii prophages encode for multiple putative virulence factors that may be implicated in the bacterium's capacity to colonize host niches, evade the host immune system, subsist in unfavorable environments, and tolerate antibiotics. Overall our results point towards a significant contribution of prophages for the dissemination and evolution of pathogenicity in A. baumannii, and highlight their clinical relevance.
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