ArticleNature communications2018
A RNA producing DNA hydrogel as a platform for a high performance RNA interference system.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 71 citations in OpenAlex.
- DNA-Based Hydrogels for Musculoskeletal Reconstruction: Harnessing Dynamic Programmability and Multimodal Therapeutic Integration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Hydrogel Conjugation: Engineering of Hydrogels for Drug Delivery.Pharmaceutics · 2025Review
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- Recent Advances and Prospects of Nucleic Acid Therapeutics for Anti-Cancer Therapy.Molecules (Basel, Switzerland) · 2024Review
- DNA Adjuvant Hydrogel-Optimized Enzymatic Cascade Reaction for Tumor Chemodynamic-Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The Application of Biomedicine in Chemodynamic Therapy: From Material Design to Improved Strategies.Bioengineering (Basel, Switzerland) · 2023Review
- Article
- Polymeric DNA Hydrogels and Their Applications in Drug Delivery for Cancer Therapy.Gels (Basel, Switzerland) · 2023Review
- RNA-DNA hybrid nano-materials for highly efficient and long lasting RNA interference effect.RSC advances · 2023Article
- Dynamic Covalent Hydrogels: Strong yet Dynamic.Gels (Basel, Switzerland) · 2022Review
- Hydrogels as functional components in artificial cell systems.Nature reviews. Chemistry · 2022Review
- Nanohydrogels: Advanced Polymeric Nanomaterials in the Era of Nanotechnology for Robust Functionalization and Cumulative Applications.International journal of molecular sciences · 2022Review
- SiRNA-templated 3D framework nucleic acids for chemotactic recognition, and programmable and visualized precise delivery for synergistic cancer therapy.Chemical science · 2021Article
- Formulation of DNA Nanocomposites: Towards Functional Materials for Protein Expression.Polymers · 2021Article
- Development, Preparation, and Biomedical Applications of DNA-Based Hydrogels.Frontiers in bioengineering and biotechnology · 2021Review
- DNA-GEL, Novel Nanomaterial for Biomedical Applications and Delivery of Bioactive Molecules.Frontiers in pharmacology · 2020Review
- pH-Sensitive Chitosan-Heparin Nanoparticles for Effective Delivery of Genetic Drugs into Epithelial Cells.Pharmaceutics · 2019Article
- Smart Bioinks as de novo Building Blocks to Bioengineer Living Tissues.Gels (Basel, Switzerland) · 2019Article
- Static DNA Nanostructures For Cancer Theranostics: Recent Progress In Design And Applications.Nanotechnology, science and applications · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
RNA interference (RNAi) is a mechanism in which small interfering RNA (siRNA) silences a target gene. Herein, we describe a DNA hydrogel capable of producing siRNA and interfering with protein expression. This RNAi-exhibiting gel (termed I-gel for interfering gel) consists of a plasmid carrying the gene transcribing siRNA against the target mRNA as part of the gel scaffold. The RNAi efficiency of the I-gel has been confirmed by green fluorescent protein (GFP) expression assay and RNA production quantification. The plasmid stability in the I-gel results in an 8-times higher transcription efficiency than that of the free plasmid. We further applied the I-gel to live cells and confirmed its effect in interfering with the GFP expression. The I-gel shows higher RNAi effect than plasmids in free form or complexed with Lipofectamine. This nanoscale hydrogel, which is able to produce RNA in a cell, provides a platform technology for efficient RNAi system.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.