ArticleScientific reports2018
Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- FateNet: an integration of dynamical systems and deep learning for cell fate prediction.Bioinformatics (Oxford, England) · 2024Article
- Characterization and antitumor effect of doxorubicin-loaded FeRSC advances · 2024Article
- Fractal dynamics of individual mitochondrial oscillators measure local inter-mitochondrial coupling.Biophysical journal · 2023Article
- Machine learning alternative to systems biology should not solely depend on data.Briefings in bioinformatics · 2022Article
- Universal dynamics of mitochondrial networks: a finite-size scaling analysis.Scientific reports · 2022Article
- Computational Models on Pathological Redox Signalling Driven by Pregnancy: A Review.Antioxidants (Basel, Switzerland) · 2022Review
- Integrated Multiomics, Bioinformatics, and Computational Modeling Approaches to Central Metabolism in Organs.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Glioma cells are resistant to inflammation‑induced alterations of mitochondrial dynamics.International journal of oncology · 2020Observational
- Modeling Cell Energy Metabolism as Weighted Networks of Non-autonomous Oscillators.Frontiers in physiology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Mitochondria serve multiple key cellular functions, including energy generation, redox balance, and regulation of apoptotic cell death, thus making a major impact on healthy and diseased states. Increasingly recognized is that biological network stability/instability can play critical roles in determining health and disease. We report for the first-time mitochondrial chaotic dynamics, characterizing the conditions leading from stability to chaos in this organelle. Using an experimentally validated computational model of mitochondrial function, we show that complex oscillatory dynamics in key metabolic variables, arising at the "edge" between fully functional and pathological behavior, sets the stage for chaos. Under these conditions, a mild, regular sinusoidal redox forcing perturbation triggers chaotic dynamics with main signature traits such as sensitivity to initial conditions, positive Lyapunov exponents, and strange attractors. At the "edge" mitochondrial chaos is exquisitely sensitive to the antioxidant capacity of matrix Mn superoxide dismutase as well as to the amplitude and frequency of the redox perturbation. These results have potential implications both for mitochondrial signaling determining health maintenance, and pathological transformation, including abnormal cardiac rhythms.
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Registered trials
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