ArticleScientific reports2018
Nighttime activities and peripheral clock oscillations depend on Wolbachia endosymbionts in flies.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Pervasive effects ofbioRxiv : the preprint server for biology · 2026Article
- Chemical biology approaches to study and target circadian clocks and their components.FEBS letters · 2026Review
- A new lexicon in the age of microbiome research.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Circadian regulation of dengue virus transmission and replication: insights into vector activity and viral dynamics.Frontiers in cellular and infection microbiology · 2024Review
- Sleep: An Essential and Understudied Process in the Biology of Blood-Feeding Arthropods.Integrative and comparative biology · 2023Review
- Food provisioning to Pardosa spiders decreases the levels of tissue-resident endosymbiotic bacteria.Scientific reports · 2023Article
- Influence of RVFV Infection on Olfactory Perception and Behavior inPathogens (Basel, Switzerland) · 2023Article
- Effect ofInsects · 2022Article
- Roles of peripheral clocks: lessons from the fly.FEBS letters · 2022Review
- Pervasive effects ofBiology letters · 2021Article
- Only time will tell: the interplay between circadian clock and metabolism.Chronobiology international · 2021Review
- The effect of the endosymbiont Wolbachia on the behavior of insect hosts.Insect science · 2020Review
- Behavioural effects of the common brain-infecting parasite Pseudoloma neurophilia in laboratory zebrafish (Danio rerio).Scientific reports · 2020Article
- Article
- Molecular mechanisms and physiological importance of circadian rhythms.Nature reviews. Molecular cell biology · 2020Review
- For Whom the Clock Ticks: Clinical Chronobiology for Infectious Diseases.Frontiers in immunology · 2020Review
- The effect of Wolbachia on gene expression in Drosophila paulistorum and its implications for symbiont-induced host speciation.BMC genomics · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Wolbachia are ubiquitous bacterial endosymbionts of arthropods and affect host gene expression. Although Wolbachia infections were suggested to modulate sleep in flies, their influence on the circadian clock remained obscure. Here, we screened bacterial symbionts in a laboratory Drosophila melanogaster colony, and observed widespread infections of wMel strain Wolbachia. We established a Wolbachia-free strain from a clock gene reporter strain, period-luciferase (per-luc). Temperature (19-29 °C)-compensated free-running periods were detected regardless of infections which may reflect the lack of wMel infections in central circadian pacemaker neurons. However, locomotor activity levels during the night or subjective night were significantly amplified in uninfected flies. Moreover, the behavioral phenotype of F1 offspring of an uninfected female and infected male resembled that of uninfected flies. This trait is consistent with maternal transmission of Wolbachia infection. Interestingly, per-luc activities in headless bodies, as an index of peripheral circadian oscillators, were severely damped in uninfected flies. Additionally, circadian amplitudes of PER immunoreactivities in Malpighian tubules were reduced in uninfected flies. These results demonstrate that Wolbachia boost fly peripheral clock oscillations and diurnal behavioral patterns. Genetic mechanisms underlying behavioral rhythms have been widely analyzed using mutant flies whereas screening of Wolbachia will be necessary for future studies.
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