ArticleEMBO reports2018
The fungal ligand chitin directly binds TLR2 and triggers inflammation dependent on oligomer size.
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Article in EMBO reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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59citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 102 citations in OpenAlex.
- Trial
- Oligosaccharide adjuvant-deferred antigen endocytosis promotes cross-presentation.Bioactive materials · 2027Article
- Chitin Is a Potent Inducer of Type 2 Airway Inflammation Independent of Endogenous Chitinolytic Activity.Allergy · 2026Article
- Acetylation and accessibility ofCell surface (Amsterdam, Netherlands) · 2026Article
- Structural insights into glycan recognition by plant immune receptors: a comparative perspective with animal innate immune systems.The Plant journal : for cell and molecular biology · 2026Review
- AtLYK4 is the major chitin receptor in Arabidopsis with N-glycosylation and ligand-interacting residues orchestrating chitin perception.Science China. Life sciences · 2026Article
- Article
- The structural language of fungal cell wall sugars in WHO priority fungi: the determinant of pathogenicity and the gateway to new therapies.Frontiers in immunology · 2026Review
- Integrated airway epithelial signaling networks linking allergen-driven inflammation to airway remodeling in asthma.Frontiers in immunology · 2026Review
- Article
- Acetylated chitosan scaffolds modulate the micro-environment and promote peripheral nerve regeneration through macrophage TLR2/4 pathway activation.Materials today. Bio · 2025Article
- Pattern recognition receptors: function, regulation and therapeutic potential.Signal transduction and targeted therapy · 2025Review
- Human chitinases and chitinase-like proteins as emerging drug targets - a medicinal chemistry perspective.RSC medicinal chemistry · 2025Review
- Bio-orthogonal Labeling of Chitin in Native Pathogenic Candida Species via the Chitin Scavenge Pathway.Journal of the American Chemical Society · 2025Article
- Chitosan immunomodulation: insights into mechanisms of action on immune cells and signaling pathways.RSC advances · 2025Review
- Antifungal Innate Immunity.Advances in experimental medicine and biology · 2025Review
- Loss ofFrontiers in cellular and infection microbiology · 2025Article
- Transkingdom mechanism of MAMP generation by chitotriosidase feeds oligomeric chitin from fungal pathogens and allergens into TLR2-mediated innate immune sensing.Frontiers in immunology · 2025Article
- Review
- PANoptosis opens new treatment options for allergic bronchopulmonary aspergillosis.The journal of allergy and clinical immunology. Global · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 9 institutions in 5 countries.
Katharina FuchsDepartment of Immunology, University of Tübingen, Tübingen, Germany.
Yamel Cardona GloriaDepartment of Immunology, University of Tübingen, Tübingen, Germany.
Olaf-Oliver WolzDepartment of Immunology, University of Tübingen, Tübingen, Germany.
Franziska HersterDepartment of Immunology, University of Tübingen, Tübingen, Germany.
Lokesh SharmaDepartment of Internal Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Microbial Pathogenesis, Center for Pulmonary Infection Research and Infection (CPIRT), New Haven, CT, USA.
Carly A DillenDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Christoph TäumerDepartment of Quantitative Proteomics and Proteome Center, University of Tübingen, Tübingen, Germany.
Sabine DickhöferDepartment of Immunology, University of Tübingen, Tübingen, Germany.
Zsofia BittnerDepartment of Immunology, University of Tübingen, Tübingen, Germany.
Truong-Minh DangDepartment of Immunology, University of Tübingen, Tübingen, Germany.
Anurag SinghUniversity Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tübingen, Tübingen, Germany.
Daniel HaischerCenter for Plant Molecular Biology, University of Tübingen, Tübingen, Germany.
Maria A SchlöffelCenter for Plant Molecular Biology, University of Tübingen, Tübingen, Germany.
Kirsten J KoymansDepartment of Medical Microbiology, University Medical Center Utrecht, CX Utrecht, The Netherlands.
Tharmila SanmugananthamDepartment of Immunology, University of Tübingen, Tübingen, Germany.
Milena KrachDepartment of Immunology, University of Tübingen, Tübingen, Germany.
Thierry RogerInfectious Diseases Service, Lausanne University Hospital, Epalinges, Switzerland.
Didier Le RoyInfectious Diseases Service, Lausanne University Hospital, Epalinges, Switzerland.
Nadine A SchillingInstitute of Organic Chemistry, University of Tübingen, Tübingen, Germany.
Felix FrauhammerDivision of Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Lloyd S MillerDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Thorsten NürnbergerCenter for Plant Molecular Biology, University of Tübingen, Tübingen, Germany.
Salomé LeibundGut-LandmannSection of Immunology, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland.
Andrea A GustCenter for Plant Molecular Biology, University of Tübingen, Tübingen, Germany.ORCID 0000-0003-0466-2792
Boris MacekDepartment of Quantitative Proteomics and Proteome Center, University of Tübingen, Tübingen, Germany.
Martin FrankBiognos AB, Göteborg, Sweden.
Cécile GouttefangeasDepartment of Immunology, University of Tübingen, Tübingen, Germany.
Charles S Dela CruzDepartment of Internal Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Microbial Pathogenesis, Center for Pulmonary Infection Research and Infection (CPIRT), New Haven, CT, USA.
Dominik HartlUniversity Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tübingen, Tübingen, Germany.
Alexander Nr WeberDepartment of Immunology, University of Tübingen, Tübingen, Germany alexander.weber@uni-tuebingen.de.ORCID 0000-0002-8627-7056
University of Tübingen · DEJohns Hopkins University · USUniversity of Lausanne · CHBiognos (Sweden) · SEGerman Cancer Research Center · DERoche (Switzerland) · CHUniversity Children's Hospital Tübingen · DEUniversity Medical Center Utrecht · NLUniversity of Zurich · CH
Funding
Host-Pneumococcal Interaction in the LungR01HL126094 · NHLBI · YALE UNIVERSITY · PI DELA CRUZ, CHARLES S · 2015 to 2019
$2.1MSTAT3-mediated immunity to Staphylococcus aureus in skinR01AR069502 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ARCHER, NATHAN K. · 2016 to 2020
$1.8MNHLBI NIH HHS R01 HL126094NIAMS NIH HHS R01 AR069502Swiss National Science Foundation 166206
Abstract
Chitin is the second most abundant polysaccharide in nature and linked to fungal infection and asthma. However,
Indexed as
AnimalsCell WallChitinChitinasesFemaleFungiHumansHydrophobic and Hydrophilic InteractionsImmunologic FactorsInflammationLigandsLymphocytesMice, Inbred C57BLMice, KnockoutTHP-1 CellsToll-Like Receptor 1ChitinChitinasesImmunologic FactorsLigandsToll-Like Receptor 1Toll-Like Receptor 2Zymosananti‐fungal innate immunitychitininflammationN‐acetyl‐glucosaminetoll‐like receptor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.