Evidence map›Paper›PMID 30337486›Full record

ArticleDevelopment (Cambridge, England)2018

John N Griffin, Samuel B Sondalle, Andrew Robson, Emily K Mis, Gerald Griffin, Saurabh S Kulkarni, Engin Deniz, Susan J Baserga, Mustafa K Khokha

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

John N GriffinPediatric Genomics Discovery Program, Departments of Pediatrics and Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA.
Samuel B SondalleDepartment of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA.
Andrew RobsonPediatric Genomics Discovery Program, Departments of Pediatrics and Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA.
Emily K MisPediatric Genomics Discovery Program, Departments of Pediatrics and Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA.
Gerald GriffinPediatric Genomics Discovery Program, Departments of Pediatrics and Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA.ORCID 0000-0002-3172-164X
Saurabh S KulkarniPediatric Genomics Discovery Program, Departments of Pediatrics and Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA.
Engin DenizPediatric Genomics Discovery Program, Departments of Pediatrics and Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA.
Susan J BasergaDepartment of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA susan.baserga@yale.edu mustafa.khokha@yale.edu.
Mustafa K KhokhaPediatric Genomics Discovery Program, Departments of Pediatrics and Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA susan.baserga@yale.edu mustafa.khokha@yale.edu.ORCID 0000-0002-9846-7076
Yale University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
GENETICS AND GENOMICS OF HUMAN DISEASET32HD007149 · NICHD · YALE UNIVERSITY · PI James P Noonan · 1985 to 2026
$8.2M
A system approach to the analysis of Heterotaxy Candiate GenesR01HD081379 · NICHD · YALE UNIVERSITY · PI KHOKHA, MUSTAFA K · 2014 to 2018
$2.7M
Key factors in human ribosome biogenesisR01GM115710 · NIGMS · YALE UNIVERSITY · PI BASERGA, SUSAN J · 2015 to 2018
$1.6M
A New Role for the PAX9 Protein in Ribosome BiogenesisR01GM122926 · NIGMS · YALE UNIVERSITY · PI BASERGA, SUSAN J · 2017 to 2019
$663k
Probing the Pathogenesis of North American Indian Childhood Cirrhosis (NAIC)F30DK109582 · NIDDK · YALE UNIVERSITY · PI SONDALLE, SAMUEL BRADY · 2016 to 2017
$57k
NICHD NIH HHS R01 HD081379NICHD NIH HHS T32 HD007149NIDDK NIH HHS F30 DK109582NIGMS NIH HHS R01 GM115710NIGMS NIH HHS R01 GM122926NIGMS NIH HHS T32 GM007205
6 · The paper itself

Abstract

A growing number of tissue-specific inherited disorders are associated with impaired ribosome production, despite the universal requirement for ribosome function. Recently, mutations in RPSA, a protein component of the small ribosomal subunit, were discovered to underlie approximately half of all isolated congenital asplenia cases. However, the mechanisms by which mutations in this ribosome biogenesis factor lead specifically to spleen agenesis remain unknown, in part due to the lack of a suitable animal model for study. Here we reveal that RPSA is required for normal spleen development in the frog,

Indexed as

Genetic Association StudiesAnimalsEmbryonic DevelopmentGene Expression Regulation, DevelopmentalHumansImmunologic Deficiency SyndromesMorpholinosMutationPrimary Immunodeficiency DiseasesRibosomal ProteinsRNA PrecursorsRNA Processing, Post-TranscriptionalSpleenXenopusXenopus ProteinsMorpholinosRibosomal ProteinsRNA PrecursorsRPSA protein, XenopusXenopus ProteinsAspleniaRibosomopathyRPSArRNA processingXenopus

Identifiers

PMID30337486
PMCPMC6215398
OpenAlexW2897672584

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.