Evidence map›Paper›PMID 30337483›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Unraveling the role of B cells in the pathogenesis of an oncogenic avian herpesvirus.

Luca D Bertzbach, Maria Laparidou, Sonja Härtle, Robert J Etches, Bernd Kaspers, Benjamin Schusser, Benedikt B Kaufer

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Luca D BertzbachInstitut für Virologie, Freie Universität Berlin, 14163 Berlin, Germany.ORCID 0000-0002-0698-5395
Maria LaparidouBiotechnologie der Reproduktion, Technische Universität München, 85354 Freising, Germany.
Sonja HärtleVeterinärwissenschaftliches Department, Institut für Tierphysiologie, Ludwig-Maximilians-Universität München, 80539 Munich, Germany.ORCID 0000-0002-7957-7827
Robert J EtchesLigand Pharmaceuticals, Inc., San Diego, CA 92121.
Bernd KaspersVeterinärwissenschaftliches Department, Institut für Tierphysiologie, Ludwig-Maximilians-Universität München, 80539 Munich, Germany.
Benjamin SchusserBiotechnologie der Reproduktion, Technische Universität München, 85354 Freising, Germany; benjamin.schusser@tum.de b.kaufer@fu-berlin.de.ORCID 0000-0002-9990-1890
Benedikt B KauferInstitut für Virologie, Freie Universität Berlin, 14163 Berlin, Germany; benjamin.schusser@tum.de b.kaufer@fu-berlin.de.ORCID 0000-0003-1328-2695
Freie Universität Berlin · DELudwig-Maximilians-Universität München · DETechnical University of Munich · DELigand Pharmaceuticals (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Marek's disease virus (MDV) is a highly oncogenic alphaherpesvirus that causes immunosuppression, paralysis, and deadly lymphomas in chickens. In infected animals, B cells are efficiently infected and are thought to amplify the virus and transfer it to T cells. MDV subsequently establishes latency in T cells and transforms CD4

Indexed as

Genome, ViralAnimalsAnimals, Genetically ModifiedAnimals, NewbornB-LymphocytesBursa of FabriciusCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChick EmbryoChickensDNA, ViralHerpesvirus 2, GallidImmunoglobulin Heavy ChainsLymphocyte CountLymphomaMarek DiseaseDNA, ViralImmunoglobulin Heavy ChainsB cellsIg knockout chickenslymphomagenesisMarek’s disease virustransgenic chickens

Identifiers

PMID30337483
PMCPMC6233081
OpenAlexW2895893082

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.