Evidence map›Paper›PMID 30337469›Full record

ArticleThe Journal of experimental medicine2018

A20-binding inhibitor of NF-κB (ABIN) 2 negatively regulates allergic airway inflammation.

Sonia Ventura, Florencia Cano, Yashaswini Kannan, Felix Breyer, Michael J Pattison, Mark S Wilson, Steven C Ley

Open access · hybridAbstract read
In one paragraph

Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. TPL2 kinase activity is required forFrontiers in immunology · 2025
    Article
  3. Article
  4. Article
  5. Long noncoding RNACell cycle (Georgetown, Tex.) · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Apolipoprotein E Signals via TLR4 to Induce CXCL5 Secretion by Asthmatic Airway Epithelial Cells.American journal of respiratory cell and molecular biology · 2020
    Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sonia VenturaThe Francis Crick Institute, London, England, UK.ORCID 0000-0002-4923-8197
Florencia CanoThe Francis Crick Institute, London, England, UK.
Yashaswini KannanThe Francis Crick Institute, London, England, UK.
Felix BreyerThe Francis Crick Institute, London, England, UK.
Michael J PattisonThe Francis Crick Institute, London, England, UK.
Mark S WilsonImmunology Discovery, Genentech Inc., South San Francisco, CA wilson.mark@gene.com.
Steven C LeyDepartment of Medicine, Imperial College London, London, England UK sley@imperial.ac.uk.ORCID 0000-0001-5911-9223
The Francis Crick Institute · GBImperial College London · GB

Funding

Cancer Research UKMedical Research Council MC_U117584209Wellcome Trust FC001103
6 · The paper itself

Abstract

TPL-2 MAP 3-kinase promotes inflammation in numerous mouse disease models and is an attractive anti-inflammatory drug target. However, TPL-2-deficient (

Indexed as

Adaptor Proteins, Signal TransducingAnimalsGene Expression Regulation, EnzymologicHypersensitivityInflammationMAP Kinase Kinase KinasesMAP Kinase Signaling SystemMiceMice, KnockoutProto-Oncogene ProteinsTumor Necrosis Factor alpha-Induced Protein 3Adaptor Proteins, Signal TransducingMap3k8 protein, mouseMAP Kinase Kinase KinasesProto-Oncogene ProteinsTnfaip3 protein, mouseTnip2 protein, mouseTumor Necrosis Factor alpha-Induced Protein 3

Identifiers

PMID30337469
PMCPMC6219730
OpenAlexW2895789558

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.