Evidence map›Paper›PMID 30337459›Full record

ArticleRNA (New York, N.Y.)2019

Influence of Mg

Thilo Hetzke, Marc Vogel, Dnyaneshwar B Gophane, Julia E Weigand, Beatrix Suess, Snorri Th Sigurdsson, Thomas F Prisner

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 35 citations in OpenAlex.

  1. Investigating the Conformational Diversity of the TMR-3 Aptamer.Journal of the American Chemical Society · 2025
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Site-Directed Spin Labeling of RNA with aMolecules (Basel, Switzerland) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Thilo HetzkeInstitute of Physical and Theoretical Chemistry and Center of Biomolecular Magnetic Resonance, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany.
Marc VogelDepartment of Biology, Technical University of Darmstadt, 64287 Darmstadt, Germany.
Dnyaneshwar B GophaneDepartment of Chemistry, Science Institute, University of Iceland, 101 Reykjavik, Iceland.
Julia E WeigandDepartment of Biology, Technical University of Darmstadt, 64287 Darmstadt, Germany.ORCID 0000-0003-4247-1348
Beatrix SuessDepartment of Biology, Technical University of Darmstadt, 64287 Darmstadt, Germany.ORCID 0000-0001-8666-6716
Snorri Th SigurdssonDepartment of Chemistry, Science Institute, University of Iceland, 101 Reykjavik, Iceland.ORCID 0000-0003-2492-1456
Thomas F PrisnerInstitute of Physical and Theoretical Chemistry and Center of Biomolecular Magnetic Resonance, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany.ORCID 0000-0003-2850-9573
Technische Universität Darmstadt · DEGoethe University Frankfurt · DEUniversity of Iceland · IS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tetracycline-binding RNA aptamer (TC-aptamer) is a synthetic riboswitch that binds the antibiotic tetracycline (TC) with exceptionally high affinity. Although a crystal structure exists of the TC-bound state, little is known about the conformational dynamics and changes upon ligand binding. In this study, pulsed electron paramagnetic resonance techniques for measuring distances (PELDOR) in combination with rigid nitroxide spin labels (Çm spin label) were used to investigate the conformational flexibility of the TC-aptamer in the presence and absence of TC at different Mg

Indexed as

RiboswitchAptamers, NucleotideBase SequenceCrystallography, X-RayElectron Spin Resonance SpectroscopyMagnesiumModels, MolecularNucleic Acid ConformationRNA StabilitySpin LabelsTetracyclineAptamers, NucleotideMagnesiumRiboswitchSpin LabelsTetracyclineconformational flexibilityDEERdivalent metal ionsPELDORsynthetic riboswitchestetracycline aptamer

Identifiers

PMID30337459
PMCPMC6298572
OpenAlexW2896588139

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.