Evidence map›Paper›PMID 30337435›Full record

SynthesisAJNR. American journal of neuroradiology2018

Outcomes of Stent Retriever versus Aspiration-First Thrombectomy in Ischemic Stroke: A Systematic Review and Meta-Analysis.

C O A Tsang, I H W Cheung, K K Lau, W Brinjikji, D F Kallmes, T Krings

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Distal mechanical thrombectomy using beveled tip aspiration zoom catheters: A preliminary study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
    Observational
  7. Article
  8. Comparative analysis of outcome-associated factors following endovascular treatment for intracranial atherosclerotic disease and cardioembolism: A subanalysis of the K-NET registry.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. [Thrombectomy : Stent retriever vs aspiration].Radiologie (Heidelberg, Germany) · 2025
    Review
  13. Article
  14. Article
  15. Utility of the novel guide catheter in mechanical thrombectomy for emergent large vessel occlusion stroke.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Standardised aspiration first approach reduces materials used and cost of thrombectomy procedure in anterior circulation large vessel occlusion stoke.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

C O A TsangFrom the Division of Neurosurgery (C.O.A.T.), Department of Surgery acotsang@hku.hk.ORCID 0000-0003-2758-3253
I H W CheungDepartment of Diagnostic Radiology (I.H.W.C.), Queen Mary Hospital, Hong Kong.ORCID 0000-0003-3211-5657
K K LauDivision of Neurology (K.K.L.), Department of Medicine, University of Hong Kong, Hong Kong.ORCID 0000-0002-8657-2418
W BrinjikjiDepartment of Medical Imaging (C.O.A.T., W.B., T.K.), Toronto Western Hospital, Toronto, Ontario, Canada.ORCID 0000-0001-5271-5524
D F KallmesDepartment of Radiology (W.B., D.F.K.), Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-8495-0040
T KringsDepartment of Medical Imaging (C.O.A.T., W.B., T.K.), Toronto Western Hospital, Toronto, Ontario, Canada.ORCID 0000-0001-6321-5787

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is ongoing debate regarding the optimal first-line thrombectomy technique for large-vessel occlusion. PURPOSE: We performed a systematic review and meta-analysis of comparative studies on stent retriever-first and aspiration-first thrombectomy. DATA SOURCES: We searched Ovid MEDLINE, PubMed, and EMBASE from 2009 to February 2018. STUDY SELECTION: Two reviewers independently selected the studies. The primary end point was successful reperfusion (TICI 2b/3). DATA ANALYSIS: Random-effects meta-analysis was used for analysis. DATA SYNTHESIS: Eighteen studies including 2893 patients were included. There was no significant difference in the rate of final successful reperfusion (83.9% versus 83.3%; OR = 0.87; 95% CI, 0.62%-1.27%) or good functional outcome (mRS 0-2) at 90 days (OR = 1.07; 95% CI, 0.80-1.44) between the stent-retriever thrombectomy and aspiration groups. The stent-retriever thrombectomy-first group achieved a statistically significant higher TICI 2b/3 rate after the first-line device than the aspiration-first group (74.9% versus 66.4%; OR = 1.53; 95% CI, 1.14%-2.05%) and resulted in lower use of a rescue device (19.9% versus 32.5%; OR = 0.36; 95% CI, 0.14%-0.90%). The aspiration-first approach resulted in a statistically shorter groin-to-reperfusion time (weighted mean difference, 7.15 minutes; 95% CI, 1.63-12.67 minutes). There was no difference in the number of passes, symptomatic intracerebral hemorrhage, vessel dissection or perforation, and mortality between groups. LIMITATIONS: Most of the included studies were nonrandomized. There was significant heterogeneity in some of the outcome variables.

conclusionsStent-retriever thrombectomy-first and aspiration-first thrombectomy were associated with comparable final reperfusion rates and functional outcome. Stent-retriever thrombectomy was superior in achieving reperfusion as a stand-alone first-line technique, with lower use of rescue devices but a longer groin-to-reperfusion time.

Indexed as

FemaleHumansMaleMiddle AgedReperfusionStentsStrokeThrombectomyTreatment Outcome

Identifiers

PMID30337435
PMCPMC7655372

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.