ArticleDevelopment (Cambridge, England)2018
Comparative genomic analysis of embryonic, lineage-converted and stem cell-derived motor neurons.
Open access · bronzeAbstract readComparative Study
In one paragraph
Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Review
- Article
- Compact transcription factor cassettes generate functional, engraftable motor neurons by direct conversion.Cell systems · 2025Article
- Canalizing cell fate by transcriptional repression.Molecular systems biology · 2024Review
- Proliferation history and transcription factor levels drive direct conversion.bioRxiv : the preprint server for biology · 2023Article
- Engineering cell fate: Applying synthetic biology to cellular reprogramming.Current opinion in systems biology · 2020Article
- Neuromuscular disease modeling on a chip.Disease models & mechanisms · 2020Review
- Generation of inner ear hair cells by direct lineage conversion of primary somatic cells.eLife · 2020Article
- Patient-Specific Cells for Modeling and Decoding Amyotrophic Lateral Sclerosis: Advances and Challenges.Stem cell reviews and reports · 2020Review
- A critical look: Challenges in differentiating human pluripotent stem cells into desired cell types and organoids.Wiley interdisciplinary reviews. Developmental biology · 2020Review
- Evolving principles underlying neural lineage conversion and their relevance for biomedical translation.F1000Research · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 2 countries.
Justin K IchidaHarvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA ichida@usc.edu meissner@molgen.mpg.de eggan@mcb.harvard.edu.ORCID 0000-0002-8827-8087
Kim A StaatsDepartment of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0000-0001-8392-7992
Brandi N Davis-DusenberyHarvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Kendell ClementHarvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0003-3808-0811
Kate E GallowayDepartment of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Kimberly N BabosDepartment of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Yingxiao ShiDepartment of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Esther Y SonHarvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Evangelos KiskinisHarvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Nicholas AtwaterHarvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Hongcang GuBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Andreas GnirkeBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Alexander MeissnerHarvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA ichida@usc.edu meissner@molgen.mpg.de eggan@mcb.harvard.edu.ORCID 0000-0001-8646-7469
Kevin EgganHarvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA ichida@usc.edu meissner@molgen.mpg.de eggan@mcb.harvard.edu.ORCID 0000-0003-4436-8467
Howard Hughes Medical Institute · USUniversity of Southern California · USBroad Institute · US
Funding
Regulatory Roles and Dynamics of Nuclear long-noncoding RNAs in PluripotencyP01GM099117 · NIGMS · HARVARD UNIVERSITY · PI RINN, JOHN LOUIS · 2011 to 2021
$21.2MCenter for Cell CircuitsP50HG006193 · NHGRI · BROAD INSTITUTE, INC. · PI REGEV, AVIV · 2011 to 2015
$15.6MUW Center for Mendelian GenomicsUM1HG006493 · NHGRI · UNIVERSITY OF WASHINGTON · PI BAMSHAD, MICHAEL JOSEPH, LEAL, SUZANNE M · 2016 to 2020
$15.3MValidating Secretory Autophagy as a Therapeutic Strategy for Diverse Forms of ALS and FTDR01NS097850 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ICHIDA, JUSTIN KAWIKA · 2016 to 2024
$5.5MTraining in Hearing & Communication NeuroscienceT32DC009975 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christopher A Shera · 2009 to 2026
$5.0MNHGRI Genome Sequencing Program Coordinating CenterU24HG008956 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI BUYSKE, STEVEN G, MATISE, TARA C. · 2016 to 2020
$4.9MLineage reprogramming for hearing loss: development of drug screening and gene therapy approachesR01DC015530 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ICHIDA, JUSTIN KAWIKA, MCMAHON, ANDREW P. · 2016 to 2020
$3.0MGeneration and characterization of tools for target-specific de novo DNA methylatR01DA036898 · NIDA · HARVARD UNIVERSITY · PI MEISSNER, ALEXANDER · 2013 to 2017
$1.7MReprogramming using small moleculesR01GM096067 · NIGMS · HARVARD UNIVERSITY · PI EGGAN, KEVIN C · 2012 to 2015
$1.2MConversion of Fibroblasts to fxnal Spinal Motor Neurons Using Defined FactorR00NS077435 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ICHIDA, JUSTIN KAWIKA · 2013 to 2015
$737kHiSeq X SequencerS10OD021553 · OD · UNIVERSITY OF WASHINGTON · PI NICKERSON, DEBORAH A · 2016 to 2016
$600kConversion of fibroblasts to functional spinal motor neurons using defined factorK99NS077435 · NINDS · HARVARD UNIVERSITY · PI ICHIDA, JUSTIN KAWIKA · 2011 to 2012
$177kNHGRI NIH HHS P50 HG006193NHGRI NIH HHS UM1 HG006493NIDA NIH HHS R01 DA036898NIDCD NIH HHS R01 DC015530NIDCD NIH HHS T32 DC009975NIGMS NIH HHS P01 GM099117NIGMS NIH HHS R01 GM096067NIH HHS S10 OD021553NINDS NIH HHS K99 NS077435NINDS NIH HHS R00 NS077435NINDS NIH HHS R01 NS097850
Abstract
Advances in stem cell science allow the production of different cell types
Indexed as
GenomicsAnimalsCell LineageEmbryo, MammalianEpigenesis, GeneticMice, Inbred C57BLMotor NeuronsPluripotent Stem CellsTranscription, GeneticDirected differentiationEmbryonic stem cellsiPS cellLineage conversionMotor neuronReprogramming
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.