ArticleBMJ open2018
B-type natriuretic peptide reference interval of newborns from healthy and pre-eclamptic women: a prospective, multicentre, cross-sectional study.
Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02574806 (Normal Values of Brain Natriuretic Peptide in Healthy Newborn), which is not on this map. Cited by 10 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Normal Values of Brain Natriuretic Peptide in Healthy Newborn
Who cites it
10 citing papers in PubMed.
- Postnatal Steroids in Preterm Infants: A Narrative Review Series-Part 3: Impacts on Growth, Neurodevelopment & Nutrition.Children (Basel, Switzerland) · 2026Review
- Postnatal Steroids in Preterm Infants: A Narrative Review Series-Part 2: Cardiovascular Impacts.Children (Basel, Switzerland) · 2026Review
- A nomogram model for predicting maternal cardiovascular complications and neonatal adverse outcomes in pregnant patients with pulmonary arterial hypertension.Annals of medicine · 2025Article
- Elevated B-type natriuretic peptide levels in pregnant women with hyperemesis gravidarum: a biomarker of cardiac stress?Revista da Associacao Medica Brasileira (1992) · 2025Article
- Early-pregnancy N-terminal pro-brain natriuretic peptide level is inversely associated with hypertensive disorders of pregnancy diagnosed after 35 weeks of gestation.Scientific reports · 2024Article
- Assessment of fluid status in neonatal dialysis: the need for new tools.Pediatric nephrology (Berlin, Germany) · 2023Article
- Review
- Prenatal Particulate Matter (PM) Exposure and Natriuretic Peptides in Newborns from Mexico City.International journal of environmental research and public health · 2021Article
- Application of B-Type Natriuretic Peptide in Neonatal Diseases.Frontiers in pediatrics · 2021Review
- Uncomplicated Monochorionic Twins: Two Normal Hearts Sharing One Placenta.Journal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo define and compare the reference interval of B-type natriuretic peptide (BNP) in healthy newborns (HN) from healthy mothers and with severe pre-eclampsia.
designProspective, multicentre, cross-sectional study.
settingFour obstetric wards of second-level academic hospitals.
participants167 HN, from 146 healthy and 21 severe pre-eclamptic women. We included newborns from healthy mothers with full-term pregnancies (38 to 42 gestational weeks), who received adequate prenatal care and who had Apgar scores ≥7 at 0 and 5 min. Newborns with chromosomopathies identified during prenatal consultations, those with respiratory distress and those with cardiac or pulmonary disease detected in the first paediatric evaluation were excluded from this study. In the group of pre-eclamptic women, we considered the same inclusion criteria, but the patients also had to meet the diagnostic criteria for pre-eclampsia with severity features, according to the American College of Obstetricians and Gynaecologists guidelines. The same exclusion criteria used for the healthy group were applied to the pre-eclampsia-associated newborn.
interventionsA single blood sample from the umbilical cord artery after delivery (vaginal or caesarean section). PRIMARY OUTCOME: Reference level of BNP in HN.
resultsIn the HN group, the median BNP was 12.15 pg/mL (IQR 7.7-16.8 pg/mL) and in the pre-eclamptic group 20.8 pg/mL (IQR 5.8-46.5 pg/mL). The reference interval for BNP in HN was 5pg/mL (95% CI 5 to 5) to 34 pg/mL (95% CI 28.4 to 38.8). We identified higher expression of BNP in newborns from pre-eclamptic women overall (p=0.037, r=0.16) and in newborns exposed to stress conditions, such as complications during labour and delivery (p=0.004, r=0.33).
conclusionsIn HN, BNP concentrations at birth were lower than reported in other similar populations. In neonates with stress conditions, the higher expression of this biomarker establishes another possible link between stress and the cardiovascular response. TRIAL REGISTRATION NUMBER: NCT02574806; Pre-results.
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