Evidence map›Paper›PMID 30337034›Full record

ReviewGastroenterology clinics of North America2018

New Insights into the Pathogenesis and Treatment of Malnutrition.

Grace E Thaxton, Peter C Melby, Mark J Manary, Geoffrey A Preidis

Abstract readReview
In one paragraph

Review in Gastroenterology clinics of North America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Grace E ThaxtonDepartment of Microbiology and Immunology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0435, USA.
Peter C MelbyCenter for Tropical Diseases, Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0435, USA.
Mark J ManaryDepartment of Pediatrics, Washington University at St. Louis, One Brookings Drive, St Louis, MO 63110-1093, USA; School of Public Health and Family Medicine, College of Medicine, Private Bag 360. Chichiri, Blantyre 3, Malawi; United States Department of Agriculture/Agricultural Research Service, Children's Nutrition Research Center, 1100 Bates Street, Houston, TX 77030, USA.
Geoffrey A PreidisSection of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Feigin Tower, 1102 Bates Avenue, Suite 860, Houston, TX 77030, USA. Electronic address: geoffrey.preidis@bcm.edu.

Funding

Nuclear receptor mediated bile acid alterations and coagulopathy in protein-energy undernutritionK08DK113114 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI PREIDIS, GEOFFREY A · 2017 to 2021
$815k
NIDDK NIH HHS K08 DK113114
6 · The paper itself

Abstract

The volume of research into the pathogenesis and treatment of malnutrition has increased markedly over the past ten years, providing mechanistic insights that can be leveraged into more effective treatment options. These discoveries have been driven by several landmark studies employing metabolomics, metagenomics, and new preclinical models. This review highlights some of the most important recent findings, focusing in particular on the emerging roles of prenatal and perinatal factors, protein deficiency, impaired gut barrier function, immune deficiency, and the intestinal microbiome.

Indexed as

HumansMalnutritionEpigeneticsImmune deficiencyIntestinal microbiotaPerinatalPrenatalProtein deficiencyTherapeutic foodsUndernutrition

Identifiers

PMID30337034
PMCPMC6484436

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.