Evidence map›Paper›PMID 30337029›Full record

ReviewGastroenterology clinics of North America2018

Brain-Gut Axis: Clinical Implications.

Julie Khlevner, Yeji Park, Kara Gross Margolis

Registry-linked trialAbstract readReview
In one paragraph

Review in Gastroenterology clinics of North America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04716738 (Sexual Dysfunction, Quality of Life and Visceral Hyperalgesia in Women With Irritable Bowel Syndrome), which is not on this map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04716738 unknown statusnot on this mapstarted 2023, after this paper: background citation

Sexual Dysfunction, Quality of Life and Visceral Hyperalgesia in Women With Irritable Bowel Syndrome

Typeobservational_patient_registrySponsorHospital General de MexicoRan2023 to 2023Enrolled20ConditionsIrritable Bowel Syndrome, Sexual DysfunctionArmsBlood analyses and coprological
3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Supplementation with Lentil (Foods (Basel, Switzerland) · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Julie KhlevnerDepartment of Pediatrics, Columbia University College of Physicians and Surgeons, 630 West 168th Street, PH 17, New York, NY 10032, USA.
Yeji ParkDepartment of Pediatrics, Columbia University College of Physicians and Surgeons, 630 West 168th Street, PH 17, New York, NY 10032, USA.
Kara Gross MargolisDepartment of Pediatrics, Columbia University College of Physicians and Surgeons, 630 West 168th Street, PH 17, New York, NY 10032, USA. Electronic address: kjg2133@cumc.columbia.edu.

Funding

MICROENVIRONMENT IN ENTERIC NEURON DEVELOPMENTR01NS015547 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GERSHON, MICHAEL D, MARGOLIS, KARA GROSS · 1985 to 2022
$7.2M
Linkage of s100a10 (p11) to enteric 5-HT4-mediated serotonergic signaling roles in GI motility, enteric nervous system development, and co-morbid dysfunction of gut and brainR01DK126644 · NIDDK · NEW YORK UNIVERSITY · PI MARGOLIS, KARA GROSS · 2021 to 2024
$1.9M
Enteric Neuronal Development as a Determinant of Intestinal InflammationK08DK093786 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARGOLIS, KARA GROSS · 2013 to 2017
$781k
NIDDK NIH HHS K08 DK093786NIDDK NIH HHS R01 DK126644NINDS NIH HHS R01 NS015547
6 · The paper itself

Abstract

This article provides an overarching view of what is currently known about the physiology of the brain-gut axis in both health and disease and how these concepts apply to irritable bowel syndrome, the most common functional gastrointestinal disorder in pediatrics.

Indexed as

BrainGastrointestinal MicrobiomeGastrointestinal TractHumansIrritable Bowel SyndromeBrain–gut axisBrain–gut–microbiome axisEnteric nervous systemIrritable bowel syndromeSerotonin

Identifiers

PMID30337029
PMCPMC6829582

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.