ArticleBiological psychiatry2019
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Article in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
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Who cites it
46 citing papers in PubMed, 87 citations in OpenAlex.
- Effects of KCNQ potassium channel modulation on ventral tegmental area activity and connectivity in individuals with depression and anhedonia.Molecular psychiatry · 2025Trial
- Activation of a locus coeruleus to ventral tegmental area noradrenergic pathway blunts binge-like ethanol intake and promotes aversive unconditioned responses in TH-ires-Cre mice.Neuropharmacology · 2026Article
- Stress History Modulates Corticotropin-Releasing Factor Neurons to Establish Resilience.Biological psychiatry global open science · 2026Article
- Gastrodin enhances stress resilience through promoting Wnt/β-Catenin-dependent neurogenesis.Journal of advanced research · 2026Article
- A paraventricular hypothalamic control of social stress susceptibility by targeting brown adipose tissue β3 adrenoceptor.Communications biology · 2026Article
- Dynamics of synchronous bursts in functionally coupled midbrain dopamine neurons driven by diverse excitatory inputs.Frontiers in systems neuroscience · 2026Article
- Neural Circuit Connections and Functions of Locus Coeruleus-Norepinephrine System.International journal of molecular sciences · 2025Review
- Untangling the multifaceted VTA responses to stress.Trends in neurosciences · 2025Review
- The Locus Coeruleus: Anatomy, Physiology, and Stress-Related Neuropsychiatric Disorders.The European journal of neuroscience · 2025Review
- Selective activation of SIGMAR1 in anterior cingulate cortex glutamatergic neurons facilitates comorbid pain in depression in male mice.Communications biology · 2025Article
- The Potential Role of Dopamine Pathways in the Pathophysiology of Depression: Current Advances and Future Aspects.CNS & neurological disorders drug targets · 2025Review
- Mapping of c-Fos Expression in Rat Brain Sub/Regions Following Chronic Social Isolation: Effective Treatments of Olanzapine, Clozapine or Fluoxetine.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Behavioral coping with chronic defeat stress in mice: A systematic review of current protocols.Neurobiology of stress · 2024Review
- Neurobiological basis of stress resilience.Neuron · 2024Review
- Midbrain glutamatergic circuit mechanism of resilience to socially transferred allodynia in male mice.Nature communications · 2024Article
- Article
- The Formation and Function of the VTA Dopamine System.International journal of molecular sciences · 2024Review
- Neuronal and Molecular Mechanisms Underlying Chronic Pain and Depression Comorbidity in the Paraventricular Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Locus Coeruleus-Dorsolateral Septum Projections Modulate Depression-Like Behaviors via BDNF But Not Norepinephrine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Chronic Desipramine Reverses Deficits in Cell Activity, Norepinephrine Innervation, and Anxiety-Depression Phenotypes in Fluoxetine-Resistant cF1ko Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
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Authors and funding
23 authors at 6 institutions in 3 countries.
Hongxing ZhangDepartment of Pharmacological Sciences, Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, New York; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, China.
Dipesh ChaudhuryDepartment of Pharmacological Sciences, Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, New York; Division of Science, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates.
Alexander R NectowLaboratory of Molecular Genetics, The Rockefeller University, New York, New York; Howard Hughes Medical Institute, Chevy Chase, Maryland.
Allyson K FriedmanDepartment of Pharmacological Sciences, Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Song ZhangDepartment of Pharmacological Sciences, Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, New York; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, China.
Barbara JuarezDepartment of Pharmacological Sciences, Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, New York; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Pharmacology, University of Washington, Seattle, Washington.
He LiuJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, China; Division of Science, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates.
Madeline L PfauFishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Hossein AleyasinFishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Affective Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Cheng JiangFishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Marshall CrumillerLaboratory of Biophysics, The Rockefeller University, New York, New York.
Erin S CalipariFishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Stacy M KuDepartment of Pharmacological Sciences, Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, New York; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Carole MorelDepartment of Pharmacological Sciences, Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Nikos TzavarasMicroscopy CORE, Icahn School of Medicine at Mount Sinai, New York, New York.
Sarah E MontgomeryDepartment of Pharmacological Sciences, Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Michelle HeDepartment of Pharmacological Sciences, Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Stephen R SaltonFishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Scott J RussoFishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Affective Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Eric J NestlerFishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Jeffrey M FriedmanLaboratory of Molecular Genetics, The Rockefeller University, New York, New York; Howard Hughes Medical Institute, Chevy Chase, Maryland.
Jun-Li CaoJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, China; Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China. Electronic address: caojl0310@aliyun.com.
Ming-Hu HanDepartment of Pharmacological Sciences, Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, New York; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Affective Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: ming-hu.han@mssm.edu.
Allen Institute for Brain Science · USIcahn School of Medicine at Mount Sinai · USXuzhou Medical College · CNHoward Hughes Medical Institute · USNew York University Abu Dhabi · AERockefeller University · US
Funding
REPRESSIVE HISTONE AND DNA METHYLATION IN RODENT DEPRESSION MODELSP50MH096890 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AKBARIAN, SCHAHRAM · 2012 to 2021
$20.2MUsing neuroeconomics to disentangle the transcriptional mechanisms underlying resilience versus susceptibility to stressR01MH051399 · NIMH · YALE UNIVERSITY · PI NESTLER, ERIC J. · 1994 to 2023
$10.2MTraining Program in NeuroscienceT32MH087004 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GEORGE W. HUNTLEY · 2009 to 2026
$4.0MNeurophysiological Basis of Susceptibility and Resilience to Social Defeat StressR01MH092306 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HAN, MING-HU · 2011 to 2015
$2.1MRapid and Long-Lasting Antidepressant Action by Targeting Midbrain HCN ChannelsR01MH120637 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RUSSO, SCOTT JAMES · 2019 to 2022
$1.8MDefining the Role of D1 and D2 Medium Spiny Neurons in Relapse to Cocaine SeekingR00DA042111 · NIDA · VANDERBILT UNIVERSITY · PI CALIPARI, ERIN · 2018 to 2020
$747kRapid and Long-Lasting Antidepressant Action by Targeting Midbrain HCN ChannelsR56MH115409 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HAN, MING-HU · 2018 to 2018
$587kRole of VTA-Amygdala Neural Circuit in Mediating Anxiety-Related BehaviorsR21MH112081 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HAN, MING-HU · 2016 to 2017
$465kDefining the Role of D1 and D2 Medium Spiny Neurons in Relapse to Cocaine SeekingK99DA042111 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CALIPARI, ERIN · 2016 to 2017
$301kIh and K+ Channels as Mechanistically Novel Targets for Depression TreatmentF32MH096464 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FRIEDMAN, ALLYSON KIMBERLY · 2011 to 2013
$163kOptogenetic dissection of neural circuits underlying alcohol drinking behaviorsF31AA022862 · NIAAA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JUAREZ, BARBARA · 2014 to 2016
$103kNIAAA NIH HHS F31 AA022862NIDA NIH HHS K99 DA042111NIDA NIH HHS R00 DA042111NIMH NIH HHS F32 MH096464NIMH NIH HHS P50 MH096890NIMH NIH HHS R01 MH051399NIMH NIH HHS R01 MH092306NIMH NIH HHS R01 MH120637NIMH NIH HHS R21 MH112081NIMH NIH HHS R56 MH115409NIMH NIH HHS T32 MH087004
Abstract
backgroundHomeostatic plasticity in mesolimbic dopamine (DA) neurons plays an essential role in mediating resilience to social stress. Recent evidence implicates an association between stress resilience and projections from the locus coeruleus (LC) to the ventral tegmental area (VTA) (LC→VTA) DA system. However, the precise circuitry and molecular mechanisms of the homeostatic plasticity in mesolimbic DA neurons mediated by the LC→VTA circuitry, and its role in conferring resilience to social defeat stress, have not been described.
methodsIn a well-established chronic social defeat stress model of depression, using projection-specific electrophysiological recordings and optogenetic, pharmacological, and molecular profiling techniques, we investigated the functional role and molecular basis of an LC→VTA circuit in conferring resilience to social defeat stress.
resultsWe found that LC neurons projecting to the VTA exhibit enhanced firing activity in resilient, but not susceptible, mice. Optogenetically mimicking this firing adaptation in susceptible mice reverses their depression-related behaviors, and induces reversal of cellular hyperactivity and homeostatic plasticity in VTA DA neurons projecting to the nucleus accumbens. Circuit-specific molecular profiling studies reveal that α
conclusionsThese findings reveal a key role of the LC→VTA circuit in mediating homeostatic plasticity in stress resilience and reveal α
Indexed as
Resilience, PsychologicalAdrenergic alpha-1 Receptor AgonistsAdrenergic alpha-1 Receptor AntagonistsAdrenergic beta-3 Receptor AgonistsAdrenergic beta-3 Receptor AntagonistsAnimalsBehavior, AnimalDopaminergic NeuronsHomeostasisLocus CoeruleusMaleMiceNeural PathwaysNeuronal PlasticityReceptors, Adrenergic, alpha-1Receptors, Adrenergic, beta-3Adrenergic alpha-1 Receptor AgonistsAdrenergic alpha-1 Receptor AntagonistsAdrenergic beta-3 Receptor AgonistsAdrenergic beta-3 Receptor AntagonistsReceptors, Adrenergic, alpha-1Receptors, Adrenergic, beta-3Adrenergic receptorsDepressionLocus coeruleusNucleus accumbensResilienceVentral tegmental area
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