ArticleThe Journal of thoracic and cardiovascular surgery2018
The hemodynamic and atrial electrophysiologic consequences of chronic left atrial volume overload in a controllable canine model.
Article in The Journal of thoracic and cardiovascular surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 20 citations in OpenAlex.
- Shunt and pace: a novel experimental model of atrial fibrillation with a volume-loaded left atrium.General thoracic and cardiovascular surgery · 2023Article
- Association of Mitral Regurgitation with Postoperative Atrial Fibrillation in Critically Ill Noncardiac Surgery Patients: A Prospective Cohort Study.International journal of general medicine · 2023Article
- The effects of cardiac stretch on atrial fibroblasts: analysis of the evidence and potential role in atrial fibrillation.Cardiovascular research · 2022Review
- Association of RDW, NLR, and PLR with Atrial Fibrillation in Critical Care Patients: A Retrospective Study Based on Propensity Score Matching.Disease markers · 2022Article
- Surgical ablation of atrial fibrillation in patients with heart failure.The Journal of thoracic and cardiovascular surgery · 2021Article
- Association between functional mitral regurgitation and recurrence of paroxysmal atrial fibrillation following catheter ablation: a prospective cohort study.The Journal of international medical research · 2021Article
- Protective effects of omega-3 fatty acids in dogs with myxomatous mitral valve disease stages B2 and C.PloS one · 2021Article
- hsa-miR-4443 inhibits myocardial fibroblast proliferation by targeting THBS1 to regulate TGF-β1/α-SMA/collagen signaling in atrial fibrillation.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Article
- The Arrhythmic Substrate for Atrial Fibrillation in Patients with Mitral Regurgitation.Journal of atrial fibrillation · 2020Article
- Associations between Intrinsic Heart Rate, P Wave and QT Interval Durations and Pulse Wave Analysis in Patients with Hypertension and High Normal Blood Pressure.International journal of environmental research and public health · 2020Article
- Mechanisms of atrial fibrillation in mitral regurgitation patients: Insights from noninvasive electrocardiographic imaging.Journal of electrocardiologyArticle
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10 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveThe purpose of this study was to determine the effects of chronic left atrial volume overload on atrial anatomy, hemodynamics, and electrophysiology using a titratable left ventriculoatrial shunt in a canine model.
methodsCanines (n = 16) underwent implantation of a shunt between the left ventricle and the left atrium. Sham animals (n = 8) underwent a median sternotomy without a shunt. Atrial activation times and effective refractory periods were determined using 250-bipolar epicardial electrodes. Biatrial pressures, systemic pressures, left atrial and left ventricle diameters and volumes, atrial fibrillation inducibility, and durations were recorded at the initial and at 6-month terminal study.
resultsBaseline shunt fraction was 46% ± 8%. The left atrial pressure increased from 9.7 ± 3.5 mm Hg to 13.8 ± 4 mm Hg (P < .001). At the terminal study, the left atrial diameter increased from a baseline of 2.9 ± 0.05 cm to 4.1 ± 0.6 cm (P < .001) and left ventricular ejection fraction decreased from 64% ± 1.5% to 54% ± 2.7% (P < .001). Induced atrial fibrillation duration (median, range) was 95 seconds (0-7200) compared with 0 seconds (0-40) in the sham group (P = .02). The total activation time was longer in the shunt group compared with the sham group (72 ± 11 ms vs 62 ± 3 ms, P = .003). The right atrial and not left atrial effective refractory periods were shorter in the shunt compared with the sham group (right atrial effective refractory period: 156 ± 11 ms vs 141 ± 11 ms, P = .005; left atrial effective refractory period: 142 ± 23 ms vs 133 ± 11 ms, P = .35).
conclusionsThis canine model of mitral regurgitation reproduced the mechanical and electrical remodeling seen in clinical mitral regurgitation. Left atrial size increased, with a corresponding decrease in left ventricle systolic function, and an increased atrial activation times, lower effective refractory periods, and increased atrial fibrillation inducibility. This model provides a means to understand the remodeling by which mitral regurgitation causes atrial fibrillation.
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