Evidence map›Paper›PMID 30336881›Full record

ArticleJACC. Clinical electrophysiology2018

Targeted Ganglionated Plexi Denervation Using Magnetic Nanoparticles Carrying Calcium Chloride Payload.

Lilei Yu, Benjamin S Scherlag, Kenneth Dormer, Isaac Rutel, Bing Huang, Xiaoya Zhou, Aneetta E Kuriakose, Kytai K Nguyen, Sunny Po

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Clinical electrophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Lilei YuDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China; Cardiovascular Research Institute, Wuhan University, Wuhan, China.
Benjamin S ScherlagSection of Cardiovascular Diseases and Heart Rhythm Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Kenneth DormerIntegrative Physiology and Pharmacology Department, College of Osteopathic Medicine, Liberty University, Lynchburg, Virginia.
Isaac RutelDepartment of Radiological Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Bing HuangDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China; Cardiovascular Research Institute, Wuhan University, Wuhan, China.
Xiaoya ZhouDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China; Cardiovascular Research Institute, Wuhan University, Wuhan, China.
Aneetta E KuriakoseDepartment of Bioengineering, the University of Texas at Arlington, Arlington, Texas.
Kytai K NguyenDepartment of Bioengineering, the University of Texas at Arlington, Arlington, Texas.
Sunny PoSection of Cardiovascular Diseases and Heart Rhythm Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma. Electronic address: sunny-po@ouhsc.edu.
University of Oklahoma Health Sciences Center · USWuhan University · CNThe University of Texas at Arlington · USLiberty University · US

Funding

Interdisciplinary Training in Nanotechnology for Cardiovascular and Lung Diseases in North TexasT32HL134613 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI NGUYEN, KYTAI TRUONG · 2017 to 2021
$1.1M
NHLBI NIH HHS T32 HL134613
6 · The paper itself

Abstract

objectivesThis study sought to develop a novel targeted delivery therapy to ablate the major atrial ganglionated plexi (GP) using magnetic nanoparticles carrying a CaCl

backgroundPrior studies indicated the role of hyperactivity of the cardiac autonomic nervous system in the genesis of atrial fibrillation.

methodsTwenty-eight male mongrel dogs underwent a bilateral thoracotomy. CaCl

resultsThe minimal effective concentration of CaCl

conclusionsCa-MNP can be magnetically targeted to suppress GP function by calcium-mediated neurotoxicity. This novel approach may be used to treat arrhythmias related to hyperactivity of the cardiac autonomic nervous system, such as early stage of atrial fibrillation, with minimal myocardial injury.

Indexed as

Atrial FibrillationCalcium ChlorideMagnetite NanoparticlesAnimalsDisease Models, AnimalDogsDrug Delivery SystemsGanglia, AutonomicHeart AtriaMaleCalcium ChlorideMagnetite Nanoparticlesatrial fibrillationautonomic nervous systemcalcium neurotoxicityganglionated pleximagnetic nanoparticles

Identifiers

PMID30336881
PMCPMC6598434
OpenAlexW2888858751

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.