ArticleBritish journal of anaesthesia2018
Propofol-induced unresponsiveness is associated with impaired feedforward connectivity in cortical hierarchy.
Article in British journal of anaesthesia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- A methodological guideline for consciousness assessment via neural electrophysiological activity.Military Medical Research · 2025Guideline
- Propofol-induced loss of responsiveness reorganizes cortical traveling waves in the human brain.bioRxiv : the preprint server for biology · 2026Article
- Neurophysiological connectomic signatures of consciousness during propofol-induced general anesthesia.Cell reports. Medicine · 2026Article
- Windows to Consciousness: The Role of Fronto-Parietal Connectivity in Anesthesia-Induced Unconsciousness.Current neuropharmacology · 2026Review
- The cognitive triad network - oscillation - behaviour links individual differences in EEG theta frequency with task performance and effective connectivity.Scientific reports · 2024Article
- Traveling waves shape neural population dynamics enabling predictions and internal model updating.bioRxiv : the preprint server for biology · 2024Article
- The nature of consciousness in anaesthesia.BJA open · 2023Review
- Analogous cortical reorganization accompanies entry into states of reduced consciousness during anesthesia and sleep.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Dynamic Recruitment of the Feedforward and Recurrent Mechanism for Black-White Asymmetry in the Primary Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Functional geometry of auditory cortical resting state networks derived from intracranial electrophysiology.PLoS biology · 2023Article
- Activation of astrocytes in the basal forebrain in mice facilitates isoflurane-induced loss of consciousness and prolongs recovery.BMC anesthesiology · 2023Article
- Selective corticocortical connectivity suppression during propofol-induced anesthesia in healthy volunteers.Cognitive neurodynamics · 2022Article
- Paradoxical markers of conscious levels: Effects of propofol on patients in disorders of consciousness.Frontiers in human neuroscience · 2022Article
- Putative Roles of Astrocytes in General Anesthesia.Current neuropharmacology · 2022Review
- Reducing Perioperative Neurocognitive Disorders (PND) Through Depth of Anesthesia Monitoring: A Critical Review.International journal of general medicine · 2021Review
- How Energy Supports Our Brain to Yield Consciousness: Insights From Neuroimaging Based on the Neuroenergetics Hypothesis.Frontiers in systems neuroscience · 2021Review
- Cortical functional connectivity indexes arousal state during sleep and anesthesia.NeuroImage · 2020Article
- Desflurane Anesthesia Alters Cortical Layer-specific Hierarchical Interactions in Rat Cerebral Cortex.Anesthesiology · 2020Article
- Article
- Level of Consciousness Is Dissociable from Electroencephalographic Measures of Cortical Connectivity, Slow Oscillations, and Complexity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 6 countries.
Funding
Abstract
backgroundImpaired consciousness has been associated with impaired cortical signal propagation after transcranial magnetic stimulation (TMS). We hypothesised that the reduced current propagation under propofol-induced unresponsiveness is associated with changes in both feedforward and feedback connectivity across the cortical hierarchy.
methodsEight subjects underwent left occipital TMS coupled with high-density EEG recordings during wakefulness and propofol-induced unconsciousness. Spectral analysis was applied to responses recorded from sensors overlying six hierarchical cortical sources involved in visual processing. Dynamic causal modelling (DCM) of induced time-frequency responses and evoked response potentials were used to investigate propofol's effects on connectivity between regions.
resultsSensor space analysis demonstrated that propofol reduced both induced and evoked power after TMS in occipital, parietal, and frontal electrodes. Bayesian model selection supported a DCM with hierarchical feedforward and feedback connections. DCM of induced EEG responses revealed that the primary effect of propofol was impaired feedforward responses in cross-frequency theta/alpha-gamma coupling and within frequency theta coupling (F contrast, family-wise error corrected P<0.05). An exploratory analysis (thresholded at uncorrected P<0.001) also suggested that propofol impaired feedforward and feedback beta band coupling. Post hoc analyses showed impairments in all feedforward connections and one feedback connection from parietal to occipital cortex. DCM of the evoked response potential showed impaired feedforward connectivity between left-sided occipital and parietal cortex (T contrast P=0.004, Bonferroni corrected).
conclusionsPropofol-induced loss of consciousness is associated with impaired hierarchical feedforward connectivity assessed by EEG after occipital TMS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.