Evidence map›Paper›PMID 30336852›Full record

Trial reportBritish journal of anaesthesia2018

Intraoperative ketamine for prevention of depressive symptoms after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.

G A Mashour, A Ben Abdallah, K O Pryor, R El-Gabalawy, P E Vlisides, E Jacobsohn, E Lenze, H R Maybrier, R A Veselis, M S Avidan and 1 more

Registry-linked trialOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of anaesthesia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01690988 (The Prevention of Delirium and Complications Associated With Surgical Treatments Multi Center Clinical Trial), which is not on this map. Cited by 33 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01690988 phase3completednot on this map

The Prevention of Delirium and Complications Associated With Surgical Treatments Multi Center Clinical Trial

TypeinterventionalSponsorWashington University School of MedicineRan2014 to 2017Enrolled746ConditionsDeliriumArmsKetamine (0.5 mg/kg), Normal Saline (placebo), Ketamine (1 mg/kg)
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.

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  13. Cortical Mechanisms Contributing to Ketamine-Induced Dissociation.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

G A MashourCenter for Consciousness Science, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address: gmashour@umich.edu.
A Ben AbdallahDepartment of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA.
K O PryorDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY, USA.
R El-GabalawyDepartment of Clinical Health Psychology, University of Manitoba, Winnipeg, MB, Canada; Department of Anesthesia and Perioperative Medicine, University of Manitoba, Winnipeg, MB, Canada.
P E VlisidesCenter for Consciousness Science, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
E JacobsohnDepartment of Anesthesia, University of Manitoba, Winnipeg, MB, Canada; Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.
E LenzeDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
H R MaybrierDepartment of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA.
R A VeselisDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY, USA; Department of Neuroanesthesiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
M S AvidanDepartment of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA.
PODCAST Research Group
Washington University in St. Louis · USUniversity of Manitoba · CAUniversity of Michigan · USCornell University · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Supplement to Network for Investigation of Delirium across the U.S (NIDUS)R24AG054259 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K. · 2016 to 2020
$4.3M
University of Michigan Anesthesiology Post-Doctoral Research Training ProgramT32GM103730 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Chad M Brummett, SACHIN KHETERPAL · 2014 to 2026
$1.9M
NCI NIH HHS P30 CA008748NIA NIH HHS R24 AG054259NIGMS NIH HHS L30 GM116069NIGMS NIH HHS T32 GM103730
6 · The paper itself

Abstract

backgroundKetamine is a general anaesthetic with anti-depressant effects at subanaesthetic doses. We hypothesised that intraoperative administration of ketamine would prevent or mitigate postoperative depressive symptoms in surgical patients.

methodsWe conducted an international, randomised clinical trial testing the effects of intraoperative administration of ketamine [0.5 mg kg

resultsThere was no significant difference on POD3 in the proportion of patients with symptoms suggestive of depression between the placebo [23/156 (14.7%)] and combined ketamine (Lo-K plus Hi-K) [61/349 (17.5%)] groups [difference = -2.7%; 95% confidence interval (CI), 5.0% to -9.4%; P=0.446]. Of the total cohort, 9.6% (64/670; 95% CI, 7.6-12.0%) had symptoms suggestive of depression before operation, which increased to 16.6% (84/505; 95% CI, 13.6-20.1%) on POD3, and decreased to 11.9% (47/395; 95% CI, 9.1-15.5%) on POD30. Of the patients with depressive symptoms on POD3 and POD30, 51% and 49%, respectively, had no prior history of depression or depressive symptoms.

conclusionsMajor surgery is associated with new-onset symptoms suggestive of depression in patients ≥60 yr old. Intraoperative administration of subanaesthetic ketamine does not appear to prevent or improve depressive symptoms. CLINICAL TRIALS REGISTRATION: NCT01690988.

Indexed as

AgedAge FactorsAnesthetics, DissociativeDepressionDouble-Blind MethodFemaleHealth StatusHumansIntraoperative PeriodKetamineMaleMiddle AgedSocioeconomic FactorsSurgical Procedures, OperativeSurveys and QuestionnairesAnesthetics, DissociativeKetamineanti-depressantdepressionketaminesurgery

Identifiers

PMID30336852
PMCPMC6208292
OpenAlexW2810390075

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.