Trial reportDrug and alcohol dependence2018
Cannabis use during alcohol treatment is associated with alcohol-related problems one-year post-treatment.
Trial report in Drug and alcohol dependence, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Acute Effects of Cannabis on Alcohol Craving and Consumption: A Randomized Controlled Crossover Trial.The American journal of psychiatry · 2026Trial
- Reductions in cigarette and cannabis use during a randomized clinical trial for alcohol use disorder.Alcohol and alcoholism (Oxford, Oxfordshire) · 2026Trial
- Effects of cannabis use on alcohol consumption in a sample of treatment-engaged heavy drinkers in Colorado.Addiction (Abingdon, England) · 2021Trial
- Cannabis craving and cross-substance substitution during cannabis treatment: Initial insights across seven cannabis use disorder clinical trials.Addictive behaviors · 2026Article
- Momentary cannabis effects on alcohol use among adults trying to quit or cut back on drinking.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026Article
- Intentions matter: How planned and unplanned alcohol and cannabis use influences outcomes.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026Article
- Cannabis retail store density and county-level mortality from injury in the state of Washington from 2009-2020.The American journal of drug and alcohol abuse · 2025Article
- Alcohol use and cannabis craving in daily life: Sex differences and associations among young adults.Alcohol, clinical & experimental research · 2024Article
- Patterns of Cannabis and Alcohol Co-Use: Substitution Versus Complementary Effects.Alcohol research : current reviews · 2022Review
- Potential for cannabis adaptation among participants in a drunk driving intervention.Journal of substance use · 2020Article
- A longitudinal examination of daily patterns of cannabis and alcohol co-use among medicinal and recreational veteran cannabis users.Drug and alcohol dependence · 2019Article
- The Effects of Marijuana Use on Transitions through Stages of Alcohol Involvement for Men and Women in the NESARC I and II.Substance use & misuse · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPrior research shows that cannabis use during treatment for Alcohol Use Disorders (AUD) is related to fewer abstinent days from alcohol, although only among those who use cannabis 1-2x/month. Here we extend prior research by assessing the relationship between the frequency of cannabis use during AUD treatment and post-treatment alcohol-related consequences.
methodsData come from the Combined Pharmacotherapies and Behavioral Interventions (COMBINE) Study, a large US randomized control trial of treatments for AUD. The current analyses include 206 cannabis users and 999 cannabis abstainers and compare longitudinal drinking data between those who used cannabis versus those who abstained during COMBINE treatment. The primary exposure was quartiles of cannabis use (Q1: less than 1x/month during treatment, Q2: 1-2x/month, Q3: 4-8x/month, Q4: 12x/month or more), with cannabis abstainers as the reference group. Outcomes were alcohol-related problems at the end of treatment and one-year post-treatment as measured by the Drinker Inventory Consequences.
resultsCompared to cannabis abstinence, the most frequent use during treatment was related to 1.44 times as many physical consequences one-year post-treatment. Cannabis use was not related to physical consequences immediately after treatment, or to intrapersonal, interpersonal, social responsibility or impulse control problems at either post-treatment time point.
conclusionsIn a sample of individuals in treatment for AUD, using cannabis 12x/month or more during treatment is associated with increased rates of physical consequences attributed to alcohol use. Individuals in treatment for AUD who also use cannabis might benefit from reducing or stopping cannabis use to avoid alcohol-related physical problems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.