Evidence map›Paper›PMID 30336367›Full record

ArticleEpilepsy research2018

Acid reflux induced laryngospasm as a potential mechanism of sudden death in epilepsy.

Ryan B Budde, Muhammad A Arafat, Daniel J Pederson, Thelma A Lovick, John G R Jefferys, Pedro P Irazoqui

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
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  9. Article
  10. Epilepsy and the gut: Perpetrator or victim?World journal of gastrointestinal pathophysiology · 2022
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Possible role ofEpilepsia open · 2019
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Ryan B BuddeWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, US.
Muhammad A ArafatDepartment of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, US.
Daniel J PedersonDepartment of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, US.
Thelma A LovickWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, US; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
John G R JefferysWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, US; Department of Pharmacology, Oxford University, Oxford, UK; Department of Biochemistry, Oxford University, Oxford, UK.
Pedro P IrazoquiWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, US; Department of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, US. Electronic address: pip@purdue.edu.
Purdue University West Lafayette · US

Funding

Mapping Stomach Autonomic Circuitry and Function for Neuromodulation of Gastric DisordersOT2OD023847 · OD · PURDUE UNIVERSITY · PI POWLEY, TERRY L. · 2016 to 2021
$17.6M
NIH HHS OT2 OD023847
6 · The paper itself

Abstract

objectiveRecent research suggests that obstructive laryngospasm and consequent respiratory arrest may be a mechanism in sudden unexpected death in epilepsy. We sought to test a new hypothesis that this laryngospasm is caused by seizures driving reflux of stomach acid into the larynx, rather than spontaneous pathological activity in the recurrent laryngeal nerve. APPROACH: We used an acute kainic acid model under urethane anesthesia to observe seizure activity in Long-Evans rats. We measured the pH in the esophagus and respiratory activity. In a subset of experiments, we blocked acid movement up the esophagus with a balloon catheter. MAIN

resultsIn all cases of sudden death, terminal apnea was preceded by a large pH drop from 7 to 2 in the esophagus. In several animals we observed acidic fluid exiting the mouth, sometimes in large quantities. In animals where acid movement was blocked, sudden deaths did not occur. No acid was detected in controls. SIGNIFICANCE: The results suggest that acid movement up the esophagus is a trigger for sudden death in KA induced seizures. The fact that blocking acid also eliminates sudden death implies causation. These results may provide insight to the mechanism of SUDEP in humans.

Indexed as

AnimalsDeath, SuddenDisease Models, AnimalEpilepsyEsophagusFemaleGastroesophageal RefluxHydrogen-Ion ConcentrationKainic AcidLaryngismusRats, Long-EvansRespirationSeizuresKainic Acid

Identifiers

PMID30336367
PMCPMC6276113
OpenAlexW2897935660

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.